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ProteomicsChemical proteomics with novel fully functionalized fragments and stringent target prioritization identifies the glutathione-dependent isomerase GSTZ1 as a lung cancer target
Photoreactive fragment-like probes have been applied to discover target proteins that constitute novel cellular vulnerabilities and to identify viable chemical hits for drug discovery. Through forming covalent bonds, functionalized probes can achieve stronger target engagement and require less effor...
ORGANISM(S): Homo sapiens (Human) 
2024-04-05 | PXD035201 | Pride
Photoreactive probes Lung cancer Gstz1 Chemical proteomics 
UnknownTarget and Agent Prioritization for the Children's Oncology Group-National Cancer Institute Pediatric MATCH Trial.
Not available
S-EPMC5963793 | biostudies-literature
ProteomicsChemical proteomics with novel fully functionalized fragments and stringent target prioritization identifies the glutathione-dependent isomerase GSTZ1 as a lung cancer target: SuTEx of GSTZ1 KD
Photoreactive fragment-like probes have been applied to discover target proteins that constitute novel cellular vulnerabilities and to identify viable chemical hits for drug discovery. Through forming covalent bonds, functionalized probes can achieve stronger target engagement and require less effor...
ORGANISM(S): Homo sapiens (Human) 
2024-04-05 | PXD037894 | Pride
Fragment-based drug discovery Gstz1 Lung cancer Chemical proteomics 
GenomicsTranscriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis
Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis
PRJNA837090 | ENA
UnknownStarGazer: A Hybrid Intelligence Platform for Drug Target Prioritization and Digital Drug Repositioning Using Streamlit.
Not available
S-EPMC9197487 | biostudies-literature
ProteomicsTranscriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis
Activated cardiac fibroblasts (CF) play a central role in cardiac fibrosis, a condition associated with most cardiovascular diseases. Conversion of quiescent into activated CF sustains heart integrity upon injury. However, permanence of CF in active state inflicts deleterious heart function effects....
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD034244 | Pride
Cardiac fibroblasts  cardiac fibrosis  myofibroblasts  transcriptomics  quantitative proteomics 
UnknownChemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target.
Not available
S-EPMC12097648 | biostudies-literature
UnknownDrug target prioritization by perturbed gene expression and network information.
Not available
S-EPMC4663505 | biostudies-literature
ProteomicsSystem-wide profiling of drug residence time by proteome integral solubility alteration assay
Most drugs used in the clinic and drug candidates target multiple proteins, and thus detailed characterization of their efficacy targets is required. While current methods rely on quantitative measurements at thermodynamic equilibrium, kinetic parameters such as the residence time of a drug on its t...
ORGANISM(S): Homo sapiens (Human) 
2023-01-06 | PXD034351 | Pride
Target engagement Drug development Thermal proteome profiling. Efficacy target Lead compound optimization Target prioritization Binding affinity Precision medicine Target occupancy 
UnknownQuantifying tumor specificity using Bayesian probabilistic modeling for drug target discovery and prioritization.
Not available
S-EPMC10028977 | biostudies-literature
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