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ProteomicsA systematic analysis of methylpeptide false discovery rates
All large-scale LC-MS/MS post-translational methylation site discovery experiments require methylpeptide spectrum matches (methyl-PSMs) to be identified at acceptably low false discovery rates (FDRs). To meet estimated methyl-PSM FDRs, methyl-PSM filtering criteria are often determined using the tar...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-01-05 | PXD002857 | Pride
Arginine methylation Heavy-methyl silac Lysine methylation False discovery rates Target-decoy approach 
MetabolomicsDIATAGeR: Triacylglycerol Annotation of Data-Independent Acquisition based Lipidomics

Triacylglycerols (TGs) are the most abundant lipids in the human body and the primary source of energy storage. Altered TGs are implicated in metabolic syndrome and detailed structural information may provide novel insights into diseases pathology. TGs are comprised of three fatty acyls with vari...

2025-03-04 | MTBLS11927 | MetaboLights
ProteomicsEnzyme and Chemical Assisted N-Terminal Blocked Peptides Analysis, ENCHANT, as a Selective Proteomics Approach Complementary to Conventional Shotgun Approach
Shotgun (bottom-up) approach has been widely applied in large-scale proteomics studies. The inherent shortages of shotgun approach lie in that the generated peptides often overwhelm the analytical capacity of current LC-MS/MS systems and that abundant proteins often hamper the identification of prot...
ORGANISM(S): Homo sapiens (Human) 
2017-11-30 | PXD007863 | Pride
Dia Single-charge ion inclusion N-terminal blocked peptides Cnbr-activated sepharose 4b 
UnknownA Scalable Approach for Protein False Discovery Rate Estimation in Large Proteomic Data Sets.
Not available
S-EPMC4563723 | biostudies-literature
UnknownOCCAM: prediction of small ORFs in bacterial genomes by means of a target-decoy database approach and machine learning techniques.
Not available
S-EPMC7673341 | biostudies-literature
ProteomicsDeepFLR Facilitates False Localization Rate Control in Phosphoproteomics
Site-specific phosphorylation events affect nearly all the cellular processes and correct phosphosite localization plays an important role in biological or medical health studies. However, direct false localization rate (FLR) control remains challenging in phosphoproteomics. Here, we propose DeepFLR...
ORGANISM(S): Homo Sapiens 
2023-04-04 | PXD037580 |
UnknownCollaborative Approach between Explainable Artificial Intelligence and Simplified Chemical Interactions to Explore Active Ligands for Cyclin-Dependent Kinase 2.
Not available
S-EPMC8973106 | biostudies-literature
UnknownA KLK4 proteinase substrate capture approach to antagonize PAR1.
Not available
S-EPMC8352894 | biostudies-literature
ProteomicsPASS-DIA: A novel data-independent acquisition approach for discovery studies
We present a strategy termed PASS-DIA (Precursor ion And Small Slice-DIA) in which MS/MS spectra are acquired with small isolation window (slices) and MS/MS spectra are interpreted with accurately measured precursor ion masses. This method enables direct application of conventional spectrum-centric ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-02 | PXD018180 | Pride
Human Data-independent acquisition Lc-ms/ms 
UnknownReanalysis of ProteomicsDB Using an Accurate, Sensitive, and Scalable False Discovery Rate Estimation Approach for Protein Groups.
Not available
S-EPMC9718969 | biostudies-literature
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