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Alkaliptosis, a pH-dependent form of regulated cell death characterized by impaired lysosomal function and lethal alkalinization, holds promise as a target for cancer therapy. Here, we utilize mass spectrometry-based drug target, transcriptomic screens and lipid metabolomics to explore the metabo...

2025-02-28 | MTBLS9283 | MetaboLights

Alkaliptosis, a pH-dependent form of regulated cell death characterized by impaired lysosomal function and lethal alkalinization, holds promise as a target for cancer therapy. Here, we utilize mass spectrometry-based drug target, transcriptomic screens, and lipid metabolomics to explore the metab...

2025-02-28 | MTBLS9288 | MetaboLights
EWSR1::FLI1 Suppresses Ribosome Biogenesis and Creates a Targetable Vulnerability in Ewing Sarcoma
Pyruvate Anaplerosis is a Targetable Vulnerability in Persistent Leukaemic Stem Cells
EWSR1::FLI1 Suppresses Ribosome Biogenesis and Creates a Targetable Vulnerability in Ewing Sarcoma
ORGANISM(S): Homo sapiens 
2026-02-23 | GSE317136 | GEO
ATGL-driven lipolysis defines a targetable metabolic vulnerability in PSMA-high prostate cancer
Ceramide Stress Defines a Targetable Metabolic Vulnerability in IDH1-Mutant Oligodendroglioma
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