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TranscriptomicsTranscription profiling of human U2OS-ERalpha cells induced with doxycycline reveals selective estrogen receptor-beta agonists repress transcription of proinflammatory genes
In addition to their role in the development and function of the reproductive system, estrogens have significant anti-inflammatory properties. Although both estrogen receptors (ERs) can mediate anti-inflammatory actions, ERbeta is a more desirable therapeutic target because ERalpha mediates the prol...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-11115 | biostudies-arrayexpress
TranscriptomicsThe stress response factors Yap6, Cin5, Phd1, and Skn7 direct targeting of the conserved co-repressor Tup1-Ssn6
The budding yeast transcriptional corepressor Tup1-Ssn6 is a model for studying similar repressosome complexes in multicellular eukaryotes. Tup1-Ssn6 does not bind DNA directly, but is directed to individual promoters by one or more DNA-binding proteins, referred to as Tup1 recruiters. We determined...
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-01 | E-GEOD-26311 | biostudies-arrayexpress
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