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GenomicsMAPT-derived circTau6 induces tau pathogenesis and neurodegeneration by encoding Tau variants
MAPT-derived circTau6 induces tau pathogenesis and neurodegeneration by encoding Tau variants
PRJNA1458083 | ENA
TranscriptomicsCancer-specific association between Tau (MAPT) and cellular pathways, clinical outcome, and drug response
Tau (MAPT) is a microtubule-associated protein causing frequent neurodegenerative diseases or inherited frontotemporal lobar degenerations. Emerging evidence for non-canonical functions of Tau in DNA protection and P53 regulation suggests its involvement in cancer. Indeed, Tau expression correlates ...
ORGANISM(S): Homo sapiens 
2022-11-27 | E-MTAB-8166 | biostudies-arrayexpress
TranscriptomicsMAPT-derived circTau6 induces tau pathogenesis and neurodegeneration by encoding Tau variants
Imbalanced accumulation of microtubule-associated protein tau containing three or four repeat domains (3R or 4R tau species) is a core feature of tauopathies, which may result from alternative splicing of the MAPT mRNA. However, specific mechanisms yielding the imbalance were underinvestigated. Here...
ORGANISM(S): Mus musculus 
2026-05-05 | GSE329170 | GEO
GenomicsDevelopment of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function [Targeted MAPT ISO-seq]
Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function [Targeted MAPT ISO-seq]
PRJNA1171850 | ENA
GenomicsAn African Ancestry–Enriched H1 Sub-Haplotype Challenges MAPT Haplotype Assignment and Reveals Distinct Tau Regulatory Programs
An African Ancestry–Enriched H1 Sub-Haplotype Challenges MAPT Haplotype Assignment and Reveals Distinct Tau Regulatory Programs
PRJNA1477858 | ENA
GenomicsAn African Ancestry–Enriched H1 Sub-Haplotype Challenges MAPT Haplotype Assignment and Reveals Distinct Tau Regulatory Programs
An African Ancestry–Enriched H1 Sub-Haplotype Challenges MAPT Haplotype Assignment and Reveals Distinct Tau Regulatory Programs
PRJNA1477859 | ENA
GenomicsAn African Ancestry–Enriched H1 Sub-Haplotype Challenges MAPT Haplotype Assignment and Reveals Distinct Tau Regulatory Programs
An African Ancestry–Enriched H1 Sub-Haplotype Challenges MAPT Haplotype Assignment and Reveals Distinct Tau Regulatory Programs
PRJNA1478492 | ENA
ProteomicsProteomics of human tau-transgenic mice reveals protein modules associated with tau pathologies
Abnormally accumulated tau protein aggregates are one of the hallmarks of dementia, including Alzheimer’s disease (AD), and are believed to play a critical role in neurodegeneration. In order to investigate proteomic alteration driven by tau aggregates, we implemented quantitative proteomics to anal...
ORGANISM(S): Mus Musculus (mouse) 
2022-07-05 | PXD031129 | JPOST Repository
UnknownDecrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Not available
S-EPMC8632305 | biostudies-literature
UnknownTau and MAPT genetics in tauopathies and synucleinopathies.
Not available
S-EPMC9310195 | biostudies-literature
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