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TranscriptomicsGene expression signatures of HO-1 in BeWo cells
Heme Oxygenase-1 (HO-1) is expressed in many cancers and influences the growth, survivall and metastasis of tumors, however, the molecular mechanisms remains largely unknown. To identify a common mechanism of action of HO-1 in cancer, we studied the global effect of HO-1 on the transcriptome of mul...
ORGANISM(S): Homo sapiens 
2011-02-15 | E-GEOD-20404 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Wnt-1 overexpressing melanoma
We aimed to analyze the effects of Wnt-1 overexpression on the mRNA expression profile of human melanoma in a mouse xenograft model and correlated the results with then presence or absence of lymphangiogenesis and metastasis. Affymetrix gene expression analysis revealed activation of canonical and n...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-GEOD-26656 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of trophoblast cell lines
Invasive extravillous trophoblasts (EVTs) of the human placenta are critically involved in successful pregnancy outcome since they remodel the uterine spiral arteries to increase blood flow and oxygen delivery to the placenta and the developing fetus. To gain more insights into their biological role...
ORGANISM(S): Homo sapiens 
2010-09-23 | E-GEOD-20510 | biostudies-arrayexpress
TranscriptomicsAdenosine deaminases that act on RNA induce reproducible changes in abundance and sequence of embryonic miRNAs
We used transgenic mouse embryos that are deficient in the two enzymatically active RNA editing enzymes ADAR1 and ADAR2 to compare relative frequencies but also sequence composition of mature miRNAs in these genetically modified backgrounds to wild-type mice by Illumina next gen sequencing. Deficien...
ORGANISM(S): Mus musculus 
2012-02-02 | E-GEOD-34626 | biostudies-arrayexpress
TranscriptomicsADAR2 reproducibly changes abundance and sequence of mature microRNAs in the mouse brain [gene expression]
Background: Adenosine deaminases that act on RNA (ADARs) bind to double-stranded and structured RNAs and deaminate adenosines to inosines. This A to I editing is widespread and required for normal life and development. Besides mRNAs and repetitive elements, ADARs can target miRNA precursors. Editing...
ORGANISM(S): Mus musculus 
2014-10-02 | E-GEOD-61067 | biostudies-arrayexpress
TranscriptomicsADAR2 reproducibly changes abundance and sequence of mature microRNAs in the mouse brain [RNA-Seq]
Background: Adenosine deaminases that act on RNA (ADARs) bind to double-stranded and structured RNAs and deaminate adenosines to inosines. This A to I editing is widespread and required for normal life and development. Besides mRNAs and repetitive elements, ADARs can target miRNA precursors. Editing...
ORGANISM(S): Mus musculus 
2014-10-02 | E-GEOD-61066 | biostudies-arrayexpress
TranscriptomicsLipoprotein lipase in chronic lymphocytic leukemia - strong biomarker with lack of functional significance
LPL co-deregulated genes after LPL specific siRNA knock-down In chronic lymphocytic leukemia (CLL), lipoprotein lipase (LPL) mRNA overexpression is an established poor prognostic marker, its function, however, is poorly understood. Measuring extracellular LPL enzymatic activity and protein, we found...
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-44247 | biostudies-arrayexpress
TranscriptomicsSequential gene expression profiling in CLL during treatment
Purpose: Accurate prediction of clinical response is the prerequisite for individualized therapy in chronic lymphocytic leukemia (CLL). We hypothesized that sequential assessment of gene expression changes early during therapy may well reflect behaviour of the leukemic clone in response to specific ...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-15490 | biostudies-arrayexpress
UnknownA genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies.
Not available
S-EPMC9976967 | biostudies-literature
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