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MetabolomicsThe metabolic background is a global player in Saccharomyces gene expression epistasis
The regulation of gene expression in response to nutrient availability is fundamental to the genotype-phenotype relationship. The metabolic-genetic make-up of the cell, as reflected in auxotrophy, is hence likely to be a determinant of gene expression. Here, we address the importance of the metaboli...
2016-12-16 | MTBLS168 | MetaboLights
TranscriptomicsRNA-seq of PBMC derived macrophages derived from healthy donors in response to lipid A or TNF alpha (Dataset_170630_SysmedIBD_RNA_HEngland)
This aim of this study is to understand changes in gene expression in PBMC-derived macrophages (from healthy individuals) in response to lipid A or TNF alpha stimulation
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-6607 | biostudies-arrayexpress
TranscriptomicsEffects of human RelA transgene on murine macrophage inflammatory responses
The NFκB family of transcription factors is a major regulator of the innate immune responses, and its dysregulation has been linked to several inflammatory diseases. In this study we focused on bone marrow derived macrophages from the recently described p65-DsRed/IκBα-eGFP transgenic strain, in whic...
ORGANISM(S): Mus musculus 
2022-03-22 | E-MTAB-11461 | biostudies-arrayexpress
TranscriptomicsRNAtag-Seq data generated from 22 host-relevant conditions in Campylobacter jejuni
RNAtag-Seq were used to investigate the transcriptomic landscape of C. jejuni under 22 growth and stress conditions, with 3 replicates from each condition. 5 extra repeats were created to replaces low-quality samples.
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 
2022-05-27 | E-MTAB-11309 | biostudies-arrayexpress
TranscriptomicsCappable-seq data for discovering condition-specific primary transcriptome in Campylobacter jejuni
The transcription start sites of the Campylobacter jejuni genome was identified by Cappable-seq, which captures primary transcripts by capping the 5´ triphosphorylated end
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 
2022-05-27 | E-MTAB-11308 | biostudies-arrayexpress
MetabolomicsGNPS Understanding the metabolic regulation of murine hematopoietic emergence
In vertebrates, lifelong supply of all the blood cell types in suitable numbers is maintained by the hematopoietic stem cells (HSCs). During development, these HSCs emerge in the aorta-gonad-mesonephros (AGM) from specialized vascular endothelium through a transdifferentiation process, called as end...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-06-02 | MSV000092085 | GNPS
MetabolomicsFunctional Metabolomics Describes the Yeast Biosynthetic Regulome
Genome-metabolism interactions enable cell growth. To probe the extent of these interactions and delineate their functional contributions, we quantified the Saccharomyces amino acid metabolome and its response to systematic gene deletion. Over one-third of coding genes, in particular those important...
2017-03-02 | MTBLS434 | MetaboLights
MetabolomicsPhospholipid acyl chain diversity controls the tissue-specific assembly of mitochondrial cardiolipins

Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for many core tasks of this organelle. Its side chain configurations are tissue-specific, functionally important and generated via post-biosynthetic remodeling. However, this process lacks the necessary specificit...

2020-05-22 | MTBLS1446 | MetaboLights
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