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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
GenomicsIdentification of the primary target of the chemotherapeutic agent CX-5461 as a late step in transcription initiation by RNA Polymerase I
In recent years, several small molecule cytotoxic drugs have been identified as potential inhibitors of ribosome biogenesis (Drygin et al., 2011; Peltonen et al., 2014a; Peltonen et al., 2014b). CX-5461 is one such drug that has also demonstrated anticancer potential for a wide range of malignancies...
ORGANISM(S): Mus musculus 
2021-04-07 | E-MTAB-9242 | biostudies-arrayexpress
UnknownDevelopment of A Standardized Opsonophagocytosis Killing Assay for Group B Streptococcus and Assessment in an Interlaboratory Study.
Not available
S-EPMC10675794 | biostudies-literature
UnknownTopoisomerase V relaxes supercoiled DNA by a constrained swiveling mechanism.
Not available
S-EPMC1976220 | biostudies-literature
UnknownA biallelic mutation in <i>IL6ST</i> encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.
Not available
S-EPMC5584118 | biostudies-literature
UnknownLong-term avelumab in advanced non-small-cell lung cancer: summaries and post hoc analyses from JAVELIN Solid Tumor.
Not available
S-EPMC9066292 | biostudies-literature
TranscriptomicsGene expression changes in the periventricular white matter of neonatal piglets at a defined 48h time point following a hypoxic-ischemic insult: a comparison of piglets left untreated and those treated with a remote post-conditioning stimulus applied to the hind leg immediately after the insult.
Remote ischemic postconditioning (RIPostC) is a promising therapeutic intervention whereby brief episodes of ischemia/reperfusion of one organ (limb) mitigate damage in another organ (brain) that has experienced severe hypoxia-ischemia. 16 Large White newborn female piglets were exposed to a tightl...
ORGANISM(S): Sus scrofa 
2016-09-21 | E-MTAB-5125 | biostudies-arrayexpress
UnknownComplete genome sequence of the complex carbohydrate-degrading marine bacterium, Saccharophagus degradans strain 2-40 T.
Not available
S-EPMC2386152 | biostudies-literature
UnknownPopulation Pharmacokinetics of Fruquintinib, a Selective Oral Inhibitor of VEGFR -1, -2, and -3, in Patients with Refractory Metastatic Colorectal Cancer.
Not available
S-EPMC12202196 | biostudies-literature
UnknownMetabolomic markers of altered nucleotide metabolism in early stage adenocarcinoma.
Not available
S-EPMC4618700 | biostudies-literature
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