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ProteomicsDissecting early AXL signaling regulators and associated phenotypes in erlotinib-treated EGFR mutant lung cancer by phophosite perturbations
Targeted therapies for receptor tyrosine kinases are effective but invariably limited by drug resistance. In EGFR-mutant lung cancer, AXL activation drives resistance to erlotinib by restoring cell survival and migration. To map these signaling mechanisms, we generated a panel of lung adenocarcinoma...
ORGANISM(S): Homo sapiens (Human) 
2026-06-14 | PXD079076 | Pride
Computational modeling Axl Luad Drug resistance Kinase biology Systems biology Egfr 
UnknownDeterminants of discordance in patients' and physicians' rating of rheumatoid arthritis disease activity.
Not available
S-EPMC3703925 | biostudies-literature
TranscriptomicsTranscriptome of mouse erythroid cells (part1) poly(A)+
We report genome-wide maps of transcription in mouse erythroid cells. We used an approach to survey poly(A)+ (mRNA) (GSE26877) and non-polyadenylated RNA poly(A)- (GSE27920) separately. This provides an alternative framework for comprehensive transcriptome profiling in mammalian cells. Two Samples. ...
ORGANISM(S): Mus musculus 
2012-01-30 | E-GEOD-26877 | biostudies-arrayexpress
ProteomicsFIH regulates cellular metabolism through hydroxylation of the deubiquitinase OTUB1.
The asparagine hydroxylase, factor inhibiting HIF (FIH) confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a general regulatory oxygen-dependent modification hav...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080695 | MassIVE
UnknownClinical features and outcomes in carriers of pathogenic desmoplakin variants.
Not available
S-EPMC11745529 | biostudies-literature
GenomicsATD
WTCCC1 project Autoimmune Thyroid Disease (ATD) samples
EGAD00000000011 | EGA
GenomicsBC
WTCCC1 project Breast cancer (BC) samples
EGAD00000000013 | EGA
GenomicsMS
WTCCC1 project Multiple Sclerosis (MS) samples
EGAD00000000012 | EGA
GenomicsWTCCC2 Ankylosing spondylitis cases - individual
WTCCC1 project Ankylosing Spondylitis (AS) samples
EGAD00000000010 | EGA
Genomics58C
WTCCC1 project samples from 1958 British Birth Cohort
EGAD00000000014 | EGA
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