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MetabolomicsUntargeted LC-HRMS Based-Plasma Metabolomics Reveals 3-O-Methyldopa as a New Biomarker of Poor Prognosis in High-Risk Neuroblastoma
Neuroblastoma (NB) is the most common extracranial malignant tumor in children. Although the survival rate of NB has improved over the years, the outcome of NB still remains poor for over 30% of cases. A more accurate risk stratification remains a key point in the study of NB and the availability of...
2023-07-14 | MTBLS4294 | MetaboLights
TranscriptomicsInsights into N-calls of mitochondrial DNA sequencing using MitoChip v2.0
Background: Developments in DNA resequencing microarrays include mitochondrial DNA (mtDNA) sequencing and mutation detection. During automated analysis to sequence mtDNA, bases can be identified as wildtype, variant, or there may be a failure to assign a base (N-call) when compared to the mtDNA refe...
ORGANISM(S): Homo sapiens 
2012-05-17 | E-GEOD-29550 | biostudies-arrayexpress
TranscriptomicsGenomics of medulloblastoma identifies four distinct molecular variants
Recent genomic approaches have suggested the existence of multiple distinct subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine how many subgroups of the disease exist, how they differ, and the extent of overlap between subgroups. We determined gene expression p...
ORGANISM(S): Homo sapiens 
2010-09-13 | E-GEOD-21140 | biostudies-arrayexpress
MetabolomicsMultiple acyl-coA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection

The human pathogen Mycobacterium tuberculosis (Mtb) devotes a significant fraction of its genome to fatty acid metabolism. Although Mtb depends on host fatty acids as a carbon source, fatty acid b-oxidation is mediated by genetically redundant enzymes, which has hampered the development of antitu...

2021-09-29 | MTBLS2374 | MetaboLights
UnknownDifferential Impact of Calcium and Vitamin D on Body Composition Changes in Post-Menopausal Women Following a Restricted Energy Diet and Exercise Program.
Not available
S-EPMC7146554 | biostudies-literature
UnknownDefining vitamin D status using multi-metabolite mathematical modelling: A pregnancy perspective.
Not available
S-EPMC7614536 | biostudies-literature
UnknownInhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction.
Not available
S-EPMC4062832 | biostudies-literature
TranscriptomicsSpinal Ependymoma Gene Expression Data
Purpose: Myxopapillary ependymoma (MPE) is a distinct histological variant of ependymoma arising commonly in the spinal cord. Despite an overall favorable prognosis, distant metastases, subarachnoid dissemination, and late recurrences have been reported. Currently the only effective treatment for M...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-66787 | biostudies-arrayexpress
TranscriptomicsThe blood transcriptional signature of chronic HCV [Illumina data]
This study characterizes the effects of chronic Hepatitis C virus (HCV) infection on gene expression by analyzing blood samples from 10 treatment-naive HCV patients and 6 healthy volunteers. Differential expression analysis of microarray data from peripheral blood mononuclear cells (PBMCs) identifie...
ORGANISM(S): Homo sapiens 
2012-10-22 | E-GEOD-40223 | biostudies-arrayexpress
UnknownAssociation between putative functional variants in the PSMB9 gene and risk of melanoma--re-analysis of published melanoma genome-wide association studies.
Not available
S-EPMC3721546 | biostudies-literature
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