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MetabolomicsThe genetic origin of evolidine, the first cyclopeptide discovered in plants, and related orbitides

Cyclic peptides are reported to have antibacterial, antifungal and other bioactivities. Orbitides are a class of cyclic peptide that are small, head-to-tail cyclized, composed of proteinogenic amino acids, and lack disulfide bonds; they are also known in several genera of the plant family Rutacea...

2020-10-14 | MTBLS1963 | MetaboLights
GenomicsGenome-Wide Transcriptome and Chromatin Analysis of Aspergillus nidulans Primary and Secondary Metabolism Reveals Crucial Function for a Kdm5-Family Histone Demethylase.
Histone posttranslational modifications (HPTMs) are involved in regulating the synthesis of fungal bioactive compounds. The exact molecular mechanisms of the silencing/activation of secondary metabolism (SM) clusters by these epigenetic events however are not yet fully understood. This work applies ...
ORGANISM(S): Aspergillus nidulans 
2016-04-01 | E-GEOD-72126 | biostudies-arrayexpress
UnknownStructural connectivity centrality changes mark the path toward Alzheimer's disease.
Not available
S-EPMC6350419 | biostudies-literature
UnknownRandomized phase III multi-institutional study of TNFerade biologic with fluorouracil and radiotherapy for locally advanced pancreatic cancer: final results.
Not available
S-EPMC4820756 | biostudies-literature
GenomicsIdentification of a novel Aire-regulating cis-regulatory element using H3K27ac ChIP-seq
Thymic central tolerance is essential to preventing autoimmunity. In medullary thymic epithelial cells (mTECs), the Autoimmune regulator (Aire) gene plays an essential role in this process by driving the expression of a diverse set of tissue-specific antigens (TSAs), which are presented and help tol...
ORGANISM(S): Mus musculus 
2015-10-23 | E-GEOD-74257 | biostudies-arrayexpress
UnknownDemographic and traditional knowledge perspectives on the current status of Canadian polar bear subpopulations.
Not available
S-EPMC4804000 | biostudies-literature
UnknownCharacterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.
Not available
S-EPMC1600006 | biostudies-literature
TranscriptomicsRarA Regulon
The experimental design was to determine the regulon of the transcriptional activator RarA. This was done by comparing the transcriptome profiles between a rarA overexpressor and the baseline control. RarA overexpression was achieved by plasmid mediated overexpression of the rarA gene and the baseli...
ORGANISM(S): Klebsiella pneumoniae 
2013-03-21 | E-MEXP-3742 | biostudies-arrayexpress
UnknownBRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma.
Not available
S-EPMC4356711 | biostudies-literature
UnknownDetermining whether Community Health Workers are 'Deployment Ready' Using Standard Setting.
Not available
S-EPMC6748218 | biostudies-literature
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