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MetabolomicsDNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming

Kidney injury initiates epithelial dedifferentiation and myofibroblast activation during the progression of chronic kidney disease (CKD). Herein, we found that the expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) was significantly increased in the kidney tissues of both CKD...

2023-01-25 | MTBLS5971 | MetaboLights
TranscriptomicsChIP-chip from H9 hESCs for RNA Polymerase II, TBP, TAF3, TAF5, TAF7, and TAF11
The general transcription factor TFIID is composed of the TATA-box-binding protein (TBP) and approximately 14 TBP-associated factors (TAFs). Here we find, unexpectedly, that undifferentiated human embryonic stem cells (hESCs) contain only six TAFs (TAFs 2, 3, 5, 6, 7 and 11), whereas following diffe...
ORGANISM(S): Homo sapiens 
2012-11-19 | E-GEOD-39312 | biostudies-arrayexpress
GenomicsGenome-wide maps of TBP-associated factor (TAF, Taf1) in S.cerevisiae
The goals of this study are to compare Next-Generation-Sequecing (NGS)-derived genome-wide occupancy of TAF (Taf1) comparing with other basal initiation components (TBP and TFIIB), histones (H3, H4, Htz1 and H4 acetylation) and histone regulator complexes (Swr1, Bdf1) in S. cerevisiae.
ORGANISM(S): Saccharomyces cerevisiae 
2017-02-14 | GSE94851 | GEO
TranscriptomicsTAF10 interacts with the GATA1 transcription factor and controls mouse erythropoiesis
We have ablated TAF10 in the erythroid compartment only by crossing the TAF10lox mice with the EpoR-Cre mice and we have studied the development of the erythroid cells in vivo. TAF10 ablation led to embryonic death at E13.5 while at E12.5 there was a clear developmental defect which was reflected in...
ORGANISM(S): Mus musculus 
2015-04-21 | E-GEOD-68083 | biostudies-arrayexpress
UnknownA novel TBP-associated factor of SL1 functions in RNA polymerase I transcription.
Not available
S-EPMC1829371 | biostudies-literature
GenomicsControl of Embryonic Stem Cell Lineage Commitment by Core Promoter Factor, TAF3 (ChIP-Seq data)
We report that TAF3, a TBP-associated core promoter factor, is highly enriched in ES cells. In addition to its role in the core promoter recognition complex TFIID, genome-wide binding studies reveal that TAF3 localizes to chromosomal regions bound by CTCF and cohesin. Enrichment for TAF3/CTCF/cohesi...
ORGANISM(S): Mus musculus 
2011-09-02 | E-GEOD-31270 | biostudies-arrayexpress
UnknownCloning and biochemical characterization of TAF-172, a human homolog of yeast Mot1.
Not available
S-EPMC108885 | biostudies-literature
GenomicsCooperative binding of DNA sequence non-specific HMGbox Factor Ubf and TBP-TAF complex SL1 determines RNA Polymerase I promoter recognition in vivo and its dysfunction underlies the Ubf-E210K neuroregression syndrome
Transcription of the >200 rRNA genes (rDNA) by RNA Polymerase I (RPI) determines as much as 35% of total nuclear RNA synthesis and is a major determinant of cell growth implicated in a range of hypertrophic and developmental disorders. Activation of the rDNA involves the formation of an extended nuc...
ORGANISM(S): Mus musculus 
2022-02-03 | E-MTAB-11385 | biostudies-arrayexpress
GenomicsSaccharomyces cerevisiae
Genome-wide maps of TBP-associated factor (TAF, Taf1) in S.cerevisiae
PRJNA374588 | ENA
UnknownCloning of murine RNA polymerase I-specific TAF factors: conserved interactions between the subunits of the species-specific transcription initiation factor TIF-IB/SL1.
Not available
S-EPMC19985 | biostudies-literature
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