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ProteomicsSelective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma
Aberrant expression of the embryonal transcription factor TBXT (also known as brachyury) drives chordoma, a rare spinal neoplasm with no effective drug therapies. The gene network regulated by TBXT is poorly understood, and strategies to disrupt its abnormal activity for therapeutic purposes are lac...
ORGANISM(S): Homo sapiens (Human) 
2025-07-31 | PXD055982 | Pride
Tbxt Chordoma Darpin Brachyury 
GenomicsChromatin interaction and histone mark signatures associated with TBXT expression in metastatic lung cancer
Chromatin interaction and histone mark signatures associated with TBXT expression in metastatic lung cancer
PRJNA1145936 | ENA
UnknownInhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death.
Not available
S-EPMC7616956 | biostudies-literature
UnknownChromatin Interaction and Histone Mark Signatures Associated With TBXT Expression in Metastatic Lung Cancer.
Not available
S-EPMC11917190 | biostudies-literature
UnknownTBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in 2D human gastruloids.
Not available
S-EPMC10659276 | biostudies-literature
GenomicsInhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death (ChIP-seq)
Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death (ChIP-seq)
PRJNA632890 | ENA
UnknownTBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in 2D human gastruloids.
Not available
S-EPMC11006400 | biostudies-literature
OtherChromatin interaction and histone mark signatures associated with TBXT expression in metastatic lung cancer
The role of TBXT in cancer formation and progression is well studied, as is its expression regulation during embryonic development, but how its expression is activated and maintained in lung cancers remains elusive. Circularized chromosome capture combined with sequencing (4C-seq) was employed to an...
ORGANISM(S): Homo sapiens 
2025-03-26 | GSE274316 | GEO
UnknownSelective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma.
Not available
S-EPMC12407079 | biostudies-literature
GenomicsSelective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma
Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma
PRJNA1158741 | ENA
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