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MetabolomicsOperation of a TCA cycle subnetwork in the mammalian nucleus

Nucleic acid and histone modifications critically depend on tricarboxylic acid (TCA) cycle for substrates and co-factors. Although a few TCA cycle enzymes have been reported in the nucleus, the corresponding pathways are considered to operate in mitochondria. Here, we show that a part of the...

2022-06-15 | MTBLS2235 | MetaboLights
MetabolomicsMitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling flux of the TCA cycle

To elucidate the function of oxidative phosphorylation (OxPhos) during B-cell differentiation we employ CD23Cre-driven expression of the dominant-negative K320E mutant of the mitochondrial helicase Twinkle (DNT). DNT-expression depletes mitochondrial DNA during B cell maturation, reduces the abun...

2026-08-21 | MTBLS4647 | MetaboLights
MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
MetabolomicsAmino acids and TCA substrates in hematopoietic cells (Part3)
Not available
ORGANISM(S): Mus musculus 
ST002126 | MetabolomicsWorkbench
MetabolomicsAmino acids and TCA substrates in hematopoietic cells (Part2)
Not available
ORGANISM(S): Mus musculus 
ST002125 | MetabolomicsWorkbench
MetabolomicsAmino acids and TCA substrates in hematopoietic cells (Part1)
Not available
ORGANISM(S): Mus musculus 
ST002124 | MetabolomicsWorkbench
MetabolomicsAmino acids and TCA substrates in hematopoietic cells (Part4)
Not available
ORGANISM(S): Mus musculus 
ST002127 | MetabolomicsWorkbench
MetabolomicsPGC1-A effect on TCA enzymes
Not available
ORGANISM(S): Mus musculus 
ST001044 | MetabolomicsWorkbench
MetabolomicsTimecourse of TCA isotopomers in LNCaP Cells
Not available
ORGANISM(S): Homo sapiens 
ST000507 | MetabolomicsWorkbench
MetabolomicsTimecourse of TCA panel in LNCaP Cells
Not available
ORGANISM(S): Homo sapiens 
ST000506 | MetabolomicsWorkbench
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