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MetabolomicsTargeted metabolomic analysis in hepatic extracts, serum, and urine of female mice gavaged with TCDD every 4 days for 28 days
TCDD is an environmental contaminant that elicits a number of hepatic effects including fat accumulation, inflammation, and fibrosis that can progress to hepatocellular carcinoma. RNA-Seq and targeted metabolomics were integrated with complementary dioxin response element (DRE) location and aryl hyd...
2017-02-02 | MTBLS225 | MetaboLights
TranscriptomicsEffects of TCDD on differentiating NHEKs
TCDD increased expression of numerous differentiation specific genes and decreased expression of numerous genes involved in mitochondrial health and redox homeostasis 8 total samples - 4 control (100% density) 4 TCDD (100% density)
ORGANISM(S): Homo sapiens 
2013-04-05 | E-GEOD-36796 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of zebrafish ovary treated with the reproductive toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
2,3,7,8-TCDD (TCDD) is a reproductive toxicant and endocrine disruptor in nearly all vertebrates, yet the mechanisms by which TCDD induces these reproductive alterations have not been fully characterized. Fish are among the most sensitive vertebrates to the toxic effects of TCDD, and even subtle ph...
ORGANISM(S): Danio rerio 
2009-04-30 | E-GEOD-4859 | biostudies-arrayexpress
TranscriptomicsAhR activation by TCDD in the ET, cortical epithelial cell line
Over activation of the aryl hydrocarbon receptor (AhR) by TCDD results ampng other phenotypes in severe thymic atrophy accompanied by immunosuppression. The link between thymic atrophy, skewed thymocyte differntiation and immunosuppression is still not fully resolved. This study investigates the TCD...
ORGANISM(S): Mus musculus 
2008-12-30 | E-GEOD-10168 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Zebrafish regenerating caudal fin tissue in the presence and absence of the dioxin TCDD
Adult zebrafish can completely regenerate their caudal fin following amputation. This complex process is initiated by the formation of an epithelial would cap over the amputation site by 12 hours post amputation (hpa). Once the cap is formed, mesenchymal cells proliferate and migrate from sites dist...
ORGANISM(S): Danio rerio 
2007-10-05 | E-GEOD-3667 | biostudies-arrayexpress
MetabolomicsUntargeted LC-MS metabolomics analysis of cecal content of mice treated with TCDD vs. vehicle control (part II)
Not available
ORGANISM(S): Mus musculus 
ST001872 | MetabolomicsWorkbench
MetabolomicsUntargeted LC-MS metabolomics analysis of cecal content of mice treated with TCDD vs. vehicle control (part I)
Not available
ORGANISM(S): Mus musculus 
ST001871 | MetabolomicsWorkbench
TranscriptomicsTranscriptomic analyses of TCDD treated zebrafish liver
To fully understand molecular toxicity of TCDD in an in vivo animal model, adult zebrafish were exposed to TCDD at 10 nM for 96 h and the livers were sampled for RNA-sequencing based transcriptomic profiling. A total of 1,058 differently expressed genes were identified based on fold-change>2 and TPM...
ORGANISM(S): Danio rerio 
2013-11-12 | E-GEOD-49915 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling of rat hypothalamic response to TCDD
In many mammals, halogenated aromatic hydrocarbon (HAH) exposure causes wasting syndrome, defined as lethal weight loss as a result of severe and persistent hypophagia. The most potent HAH in causing wasting is 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD), which exerts its toxic effects through the ar...
ORGANISM(S): Rattus norvegicus 
2014-12-23 | E-GEOD-61039 | biostudies-arrayexpress
TranscriptomicsPatterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats
The dioxin congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a wide range of toxic effects in rodent species, all of which are mediated by a ligand-dependent transcription-factor, the aryl hydrocarbon receptor (AHR). The Han/Wistar (Kuopio) (H/W) strain shows exceptional resistance to many ...
ORGANISM(S): Rattus norvegicus 
2011-11-14 | E-GEOD-13513 | biostudies-arrayexpress
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