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ProteomicsHeteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C
Neurodegenerative diseases are characterised by the abnormal filamentous assembly of specific proteins in the central nervous system1. Human genetic studies established a causal role for protein assembly in neurodegeneration2. However, the underlying molecular mechanisms remain largely unknown, whic...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055345 | Pride
Frontotemporal dementia Neurodegenerative disease Tdp-43 and tmem106b 
UnknownTMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy.
Not available
S-EPMC8812793 | biostudies-literature
ProteomicsAmyloid fibrils in disease FTLD-TDP are composed of TMEM106B, rather than TDP-43
FTLD is the third most common neurodegenerative condition, following only Alzheimer's and Parkinson's diseases. FTLD typically presents in 45-64-year-olds with behavioral changes or progressive decline of language skills. The subtype FTLD-TDP is characterized by certain clinical symptoms and patholo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-22 | MSV000088430 | MassIVE
UnknownAmyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Not available
S-EPMC9844993 | biostudies-literature
UnknownThe TMEM106B locus and TDP-43 pathology in older persons without FTLD.
Not available
S-EPMC4351662 | biostudies-literature
UnknownLysosomal escape and TMEM106B fibrillar core determine TDP-43 seeding outcomes.
Not available
S-EPMC12767511 | biostudies-literature
UnknownGenome-wide association studies of TDP-43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B.
Not available
S-EPMC12598407 | biostudies-literature
UnknownTMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia.
Not available
S-EPMC10841341 | biostudies-literature
TranscriptomicsTMEM106B deficiency leads to alterations in lipid metabolism and obesity in the TDP-43Q331K knock-in mouse model
The TMEM106B gene, encoding a lysosomal membrane protein, is closely linked with brain aging and neurodegeneration. TMEM106B has been identified as a risk factor for several neurodegenerative diseases characterized by aggregation of the RNA-binding protein TDP-43, including frontotemporal lobar dege...
ORGANISM(S): Mus musculus 
2025-01-21 | GSE287573 | GEO
TranscriptomicsTDP-43 nuclear loss in FTD-ALS causes widespread alternative polyadenylation
In frontotemporal dementia and amyotrophic lateral sclerosis, the RNA-binding protein TDP-43 is depleted from the nucleus. TDP-43 loss leads to cryptic exon inclusion but a role in other RNA processing events remains unresolved. Here, we show that loss of TDP-43 causes widespread changes in alternat...
ORGANISM(S): Homo sapiens 
2025-11-20 | GSE252892 | GEO
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