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TranscriptomicsBone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions
Liver macrophages play a major role in the control of infections in the liver and in the pathology associated with chronic liver diseases. It was recently shown that liver macrophages can have two different origins, however, the extent to which these populations are functionally distinct remains to ...
ORGANISM(S): Mus musculus 
2016-07-28 | E-MTAB-4954 | biostudies-arrayexpress
TranscriptomicsASC controls T-bet-dependent CTL differentiation and defines transplant outcome independent of the inflammasome
The adaptor protein ASC is known to facilitate caspase-1 activation essential for innate host immunity via the formation of the inflammasome complex - a multi-protein structure responsible for processing IL-1beta and IL-18 to their active moieties. Here we demonstrate that ASC-deficient CD8+ T cell...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-78755 | biostudies-arrayexpress
TranscriptomicsTc17 cells are a pro-inflammatory, plastic lineage of pathogenic CD8+ T-cells that induce GVHD without anti-leukemic effects
IL-17-producing cells are important mediators of graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (SCT). Here we demonstrate that a distinct CD8+ Tc17 population develops rapidly after SCT but fails to maintain lineage fidelity such that they are unrecognizable in the abse...
ORGANISM(S): Mus musculus 
2015-09-13 | E-GEOD-70931 | biostudies-arrayexpress
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