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MetabolomicsPodophyllotoxin-induced nephrotoxicity via the microbiota-gut-kidney axis in SD rats based on the toxicological evidence chain (TEC) concept
Podophyllotoxin (PPT) exhibits limited clinical utility due to its nephrotoxicity, and its underlying mechanisms remain poorly understood. This study employs the toxicological evidence chain (TEC) framework and integrated multi-omics analyses to investigate the potential involvement of the microbiot...
2026-06-25 | MTBLS14854 | MetaboLights
ProteomicsTec kinase deficiency in macrophages
Previous work has shown conflicting roles for Tec family kinases in regulation of Toll-like receptor (TLR)-dependent signalling in myeloid cells. In the present study, we performed a detailed investigation of the role of Btk and Tec kinases in regulating TLR signalling in several types of primary mu...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD002031 | Pride
Tec kinase macrophage 
GenomicsEscherichia coli strain:tEC
Escherichia coli strain:tEC Genome sequencing and assembly
PRJNA308525 | ENA
TranscriptomicsGenome-wide analysis of the TEC-specific Hipk2 gene knockout in mouse medullary thymic epithelial cells (mTECs)
Analysis of the role of Hipk2 in regulating gene expression in medullary thymic epithelial cells. The whole genome gene signatures of purified mTEC subsets (CD80 low, CD80 high) from TEC-specific Hipk2 knockout mice were compared to mating wildtype control mice (floxed, Cre-). Results provide the up...
ORGANISM(S): Mus musculus 
2015-01-05 | E-GEOD-63432 | biostudies-arrayexpress
TranscriptomicsCharting the age-altered thymic epithelial cell differentiation by lineage tracing from a beta 5-t expressing TEC progenitor
TEC progenitors that express beta 5-t contribute to both the cortical and medullary TEC compartments. Our initial experiments across ageing thymi identified a population of potential progenitor TECs which expanded with age, and appears to be a progenitor population for mTEC. These lineage tracing ex...
ORGANISM(S): Mus musculus 
2020-09-14 | E-MTAB-8737 | biostudies-arrayexpress
TranscriptomicsAn integrated approach to profile lung tumor endothelial cell heterogeneity across species and models and to identify angiogenic candidates
Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species (human/mouse) and models (in vivo/vitro) remains poorly inventoried at the single-cell-level. We single-cell RNA-sequenced 56,771 ECs from human/mouse (peri)-tumoral lung and cultured human lung TECs, detected 17 ...
ORGANISM(S): Mus musculus 
2020-05-20 | E-MTAB-7458 | biostudies-arrayexpress
TranscriptomicsGene expression in thymic epithelial cells [RNA-seq]
This study set out to assay the (polyA+) transcriptomes of specific FACS sorted populations of mouse thymic epithelial cells (TEC). Two biological replicates of each of seven murine TEC populations were FACS sorted and sequenced.
ORGANISM(S): Mus musculus 
2014-09-04 | E-GEOD-53110 | biostudies-arrayexpress
TranscriptomicsAn integrated approach to profile lung tumor endothelial cell heterogeneity across species and models and to identify angiogenic candidates
Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species (human/mouse) and models (in vivo/vitro) remains poorly inventoried at the single-cell-level. We single-cell RNA-sequenced 56,771 ECs from human/mouse (peri)-tumoral lung and cultured human lung TECs, detected 17 ...
ORGANISM(S): Homo sapiens 
2019-12-30 | E-MTAB-6308 | biostudies-arrayexpress
TranscriptomicsIdentification of a stable molecular signature in breast tumor endothelial cells that persists ex vivo
Long-term, in vitro propagation of tumor-specific endothelial cells (TEC) allows for ex vivo functional studies and gene expression profiling of clonally-derived, well-characterized subpopulations. Using a genetically-engineered mouse model (GEMM) of mammary adenocarcinoma (C3-TAg), we have optimize...
ORGANISM(S): Mus musculus 
2014-03-21 | E-GEOD-50555 | biostudies-arrayexpress
TranscriptomicsDifferential features of Aire-induced and Aire-independent promiscuous gene expression in thymic epithelial cells
Promiscuous gene expression (pGE) of numerous self-antigens in thymic epithelial cells (TEC) enables the elimination of self-reactive T cells. The autoimmune regulator (Aire) is the only known molecular determinant driving pGE in the thymus but the existence of Aire-independent mechanisms has been i...
ORGANISM(S): Mus musculus 
2015-05-19 | E-GEOD-65617 | biostudies-arrayexpress
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