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TranscriptomicsGenotyping of human basal cell carcinomas unveils uniparental disomy as a key domatic event.
Affymetrix 10K SNP mapping arrays were used to profile 14 basal cell carcinomas (BCCs) with matched blood DNA samples. Loss of heterozygosity (LOH) and copy number abnormality (CNA) profiles were derived from each tumour-blood pair. Experiment Overall Design: 14 BCC/Blood pairs were used in this stu...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2959 | biostudies-arrayexpress
TranscriptomicsUpregulation of FOXM1 Induces Genomic Instability in Human Epidermal Keratinocytes
Genome-wide 10k SNP profiling of FOXM1B-transduced N/TERT and primary normal human epidermal keratinocytes (NHEK). The aim of this study was to study the cancer initiation role of UVB and FOXM1B upregulation in NHEK. Upregulation of FOXM1B alone (without UVB) was found to directly induce genomic ins...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-16937 | biostudies-arrayexpress
TranscriptomicsFOXM1 Orchestrates a Global Methylation Signature that Mimics the Cancer Epigenome
Aberrant upregulation of a single oncogene FOXM1 in primary normal human oral epithelial cells orchestrated a cancer-like methylome landscape This study have identified a unique FOXM1-induced epigenetic signature which may have potentials as biomarkers for early oral cancer screening, diagnostic and...
ORGANISM(S): Homo sapiens 
2012-04-18 | E-GEOD-31767 | biostudies-arrayexpress
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