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GenomicsG-Quadruplex structures are stable and detectable in human genomic DNA.
The G-quadruplex is an alternative DNA structural motif that is considered to be functionally important in the mammalian genome. Herein, we address the hypothesis that G-quadruplex structures can exist within double-stranded genomic DNA using a G-quadruplex-specific probe. An engineered antibody is ...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-45241 | biostudies-arrayexpress
ProteomicsIntegrating Proteomics and Bioinformatics Methods for the Identification of Breast Cancer Biomarkers Interacting with Telomeric G-Quadruplex
The identification of reliable biomarkers is imperative for enhancing early detection, prognosis, and treatment of breast cancer. This study investigates a human telomeric dimeric G-quadruplex (G4) model, Tel46, which has been functionalized on Controlled Pore Glass (CPG) support, as a novel tool fo...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD059593 | Pride
Bioinformatics Telomeric g-quadruplex Proteomics Dna-protein interactions. Breast cancer biomarkers 
ProteomicsIntegrating Proteomics and Bioinformatics Methods for the Identification of Breast Cancer Biomarkers Interacting with Telomeric G-Quadruplex
The identification of reliable biomarkers is imperative for enhancing early detection, prognosis, and treatment of breast cancer. This study investigates a human telomeric dimeric G-quadruplex (G4) model, Tel46, which has been functionalized on Controlled Pore Glass (CPG) support, as a novel tool fo...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD059597 | Pride
Bioinformatics Telomeric g-quadruplex Proteomics Dna-protein interactions. Breast cancer biomarkers 
UnknownHuman Telomeric G-Quadruplex Structures and G-Quadruplex-Interactive Compounds.
Not available
S-EPMC5516791 | biostudies-literature
UnknownStructure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures.
Not available
S-EPMC2817458 | biostudies-literature
UnknownDisordering of human telomeric G-quadruplex with novel antiproliferative anthrathiophenedione.
Not available
S-EPMC3216923 | biostudies-literature
UnknownInsights into telomeric G-quadruplex DNA recognition by HMGB1 protein.
Not available
S-EPMC6765150 | biostudies-literature
UnknownMolecular Recognition of the Hybrid-2 Human Telomeric G-Quadruplex by Epiberberine: Insights into Conversion of Telomeric G-Quadruplex Structures.
Not available
S-EPMC6192034 | biostudies-literature
UnknownDual recognition of the human telomeric G-quadruplex by a neomycin-anthraquinone conjugate.
Not available
S-EPMC3977216 | biostudies-literature
UnknownAn intramolecular G-quadruplex structure is required for binding of telomeric repeat-containing RNA to the telomeric protein TRF2.
Not available
S-EPMC3528108 | biostudies-literature
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