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ProteomicsVenomics across the Bothrops neuwiedi species complex reveals a P-III SVMP/K49-PLA2 dichotomy and a remarkable paraspecific neutralization of the Brazilian pentabothropic antivenom
Snakes of the Bothrops neuwiedi complex have a widespread distribution, and represent medically important species in Brazil. Here, we report a compositional and functional profiles of the venom of seven species of the B. neuwiedi group: B. mattogrossensis, B. pauloensis, B. pubescens, B. diporus, B....
ORGANISM(S): Bothrops mattogrossensis 
2026-02-23 | PXD066646 | Pride
Bothrops venom variability  venom phenotypic dichotomy  antivenomics  immunological crossreactivity  b. neuwiedi clade 
UnknownEpigenetic and metabolic rewiring in metastatic pheochromocytomas and paragangliomas driven by SDHB mutations.
Pheochromocytomas and paragangliomas (PPGLs) with SDHB mutations frequently develop metastases, but the molecular mechanisms driving this progression remain unclear. Here we show that SDHB-mutant metastatic PPGLs display an amplified hypermethylation signature, particularly in genes involved in neur...
S-EPMC12913883 | biostudies-literature
ProteomicsChromosome-level reference genome for the medically important Arabian horned viper (Cerastes gasperettii)
Venomous animals have traditionally been studied from a proteomic (but also transcriptomic) perspective, often overlooking the study of venom from a genomic point of view until recently. The rise of genomics has led to an increase in the number of reference genomes for non-model organisms, including...
ORGANISM(S): Cerastes gasperettii 
2025-02-18 | PXD060783 | Pride
Toxin evolution  microsynteny  genomics  transcriptomics 
ProteomicsChromosome-level reference genome for the medically important Arabian horned viper (Cerastes gasperettii)
Venomous animals have traditionally been studied from a proteomic (but also transcriptomic) perspective, often overlooking the study of venom from a genomic point of view until recently. The rise of genomics has led to an increase in the number of reference genomes for non-model organisms, including...
ORGANISM(S): Cerastes gasperettii 
2025-02-18 | PXD060777 | Pride
Toxin evolution  microsynteny  genomics  transcriptomics 
UnknownEffectiveness of an intensive E-mail based intervention in smoking cessation (TABATIC study): study protocol for a randomized controlled trial.

Background

Intensive interventions on smoking cessation increase abstinence rates. However, few electronic mail (E-mail) based intensive interventions have been tested in smokers and none in primary care (PC) setting. The aim of the present study is to evaluate the effectiveness of an intens...
S-EPMC3648415 | biostudies-literature
UnknownEpidemiology, ventilation management and outcomes of COVID-19 ARDS patients versus patients with ARDS due to pneumonia in the Pre-COVID era.

Background

Ventilation management may differ between COVID-19 ARDS (COVID-ARDS) patients and patients with pre-COVID ARDS (CLASSIC-ARDS); it is uncertain whether associations of ventilation management with outcomes for CLASSIC-ARDS also exist in COVID-ARDS.

Methods

Individual patient ...
S-EPMC11330602 | biostudies-literature
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