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TranscriptomicsPrimary and secondary CD8 T cells during acute and chronic LCMV infection
Understanding the response of memory CD8 T cells to persistent antigen re-stimulation and the role of CD4 T cell help is critical to the design of successful vaccines for chronic diseases. However, studies comparing the protective abilities and qualities of memory and naïve cells have been mostly pe...
ORGANISM(S): Mus musculus 
2011-08-22 | E-GEOD-30962 | biostudies-arrayexpress
TranscriptomicsExpression data from B6, Sle1b and Sle1b.BACSlamf6-H1 CD4+ T cells
We recently showed that the Slamf6 protein isoform Slamf6-H1 markedly diminishes T cell–dependent disease upon introduction of a Slamf6-H1–expressing transgene into the lupus-prone Sle1b mouse, which lacks this isoform. In this study we purified CD4+ T cells from Sle1b, Sle1b.Slamf6-H1, or B6 mice a...
ORGANISM(S): Mus musculus 
2013-04-23 | E-GEOD-31733 | biostudies-arrayexpress
TranscriptomicsSLAMF1/CD150 regulates chemotaxis, autophagy and therapy responses in chronic lymphocytic leukemia patients
This work shows that signaling-lymphocytic-activation-molecule-1 (SLAMF1), a co-stimulatory molecule and a microbial sensor, is expressed by normal CD19+/CD5+ B-lymphocytes. Its expression is lost in a subset of patients with chronic lymphocytic leukemia (CLL) characterized by an aggressive form of ...
ORGANISM(S): Homo sapiens 
2015-05-23 | E-GEOD-69165 | biostudies-arrayexpress
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