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GenomicsCell-autonomous function of LSH ATPase in de novo DNA methylation
Purpose: We aimed to determine whether the expression of either wild-type or catalytically inactive LSH, carrying a single point mutation in its ATP binding site (K237Q), could restore the levels and patterns of DNA methylation in Lsh-/- mouse embryonic fibroblasts (MEFs). Methods: Lsh-/- MEFs were...
ORGANISM(S): Mus musculus 
2016-07-21 | E-GEOD-64384 | biostudies-arrayexpress
GenomicsSmchd1 dependent and independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.
X chromosome inactivation involves multiple levels of chromatin modification, established progressively and in a stepwise manner during early development. The chromosomal protein Smchd1 has recently been shown to play an important role in DNA methylation of CpG islands (CGIs), a late step in the X i...
ORGANISM(S): Mus musculus 
2012-10-15 | E-GEOD-37333 | biostudies-arrayexpress
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