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TranscriptomicsThe role of Ternary Complex factors in T-cell Positive Selection
Removal of the transcription factor SAP1a member of the Ternary Complex Factor (TCF) group of transcription factors which in conjunction with Serum Response Factor (SRF) has been shown to have a profound effect on positive selection in the thymus. When another TCF Elk1 is knocked out in mice there i...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-21546 | biostudies-arrayexpress
ProteomicsSMARCA2, VHL Binary and Ternary Complex formation with ACBi1, PROTAC1, and PROTAC2
Interrogration of impacts on Hydrogen Deuterium Exchange of ligand binding using heterobifunctional molecules ACBi1(SiTX-0038406), PROTAC1(SiTX-0038404) and PROTAC2(SiTX-0038405) on target proteins SMARCA2 and VHL both in the binary and Ternary modes.
ORGANISM(S): Homo sapiens (Human) 
2022-10-12 | PXD033849 | Pride
Hdx-ms 
TranscriptomicsExpression data from serum-stimulated NIH 3T3 cells stably expressing control (pLKO.1) vector or shRNAs targeting Net or Sap-1
Although much is known about focal adhesion signaling induced by cell adhesion, how adhesion directs changes in transcription to control cell behavior is far less understood. Here we describe a novel mechanism by which changes in adhesion switch the activities of the mitogen-activated protein kinas...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-26640 | biostudies-arrayexpress
ProteomicsA binding site hotspot map of the FKBP12–rapamycin–FRB ternary complex by photo-affinity labeling and mass spectrometry-based proteomics
PRIDE > Archive > PXD013420 Project PXD013420 Download Project Files Summary Title A binding site hotspot map of the FKBP12–rapamycin–FRB ternary complex by photo-affinity labeling and mass spectrometry-based proteomics Description Structural characterization of small molecule binding site hotspo...
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD014283 | Pride
Photo-affinity labeling Structural proteomics 
ProteomicsA binding site hotspot map of the FKBP12–rapamycin–FRB ternary complex by photo-affinity labeling and mass spectrometry-based proteomics
Structural characterization of small molecule binding site hotspots within the global proteome is uniquely enabled by photo-affinity labeling (PAL) coupled with chemical enrichment and unbiased analysis by mass spectrometry (MS). MS-based binding site hotspot maps provide structural resolution of in...
ORGANISM(S): Homo sapiens (Human) 
2019-07-17 | PXD014319 | Pride
Photo-affinity labeling Structural protemics 
ProteomicsA binding site hotspot map of the FKBP12–rapamycin–FRB ternary complex by photo-affinity labeling and mass spectrometry-based proteomics
Structural characterization of small molecule binding site hotspots within the global proteome is uniquely enabled by photo-affinity labeling (PAL) coupled with chemical enrichment and unbiased analysis by mass spectrometry (MS). MS-based binding site hotspot maps provide structural resolution of in...
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD013420 | Pride
Photo-affinity labeling Natural product Structural proteomics 
GenomicsA Ternary-code DNA Methylome Atlas of Mouse Tissues
A Ternary-code DNA Methylome Atlas of Mouse Tissues
PRJNA1330146 | ENA
GenomicsTranscription Factors Form a Ternary Complex with NIPBL/MAU2 to Localize Cohesin at Enhancers
Transcription Factors Form a Ternary Complex with NIPBL/MAU2 to Localize Cohesin at Enhancers
PRJNA1189196 | ENA
TranscriptomicsmTORC1 and CK2 coordinate ternary and eIF4F complex assembly
mRNA translation plays a major role in homeostasis, whereas its dysregulation underpins a variety of pathological states including cancer, metabolic syndrome and neurological disorders. Ternary complex (TC) and eIF4F complex assembly are two major rate-limiting steps in translation initiation that a...
ORGANISM(S): Homo sapiens 
2016-04-01 | GSE76766 | GEO
GenomicsA Ternary-code DNA Methylome Atlas of Mouse Tissues
A Ternary-code DNA Methylome Atlas of Mouse Tissues
PRJNA1228665 | ENA
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