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TranscriptomicsExpression data from BM-CD138+, obtained from newly diagnosed Multiple Myeloma patients
A subanalysis of the GIMEMA-MMY-3006 trial was performed to characterize treatment-emergent peripheral neuropathy (PN) in patients randomized to thalidomide-dexamethasone (TD) or bortezomib-TD (VTD) before and after double autologous transplantation (ASCT) for multiple myeloma (MM). 236 patients ran...
ORGANISM(S): Homo sapiens 
2014-12-23 | E-GEOD-58133 | biostudies-arrayexpress
TranscriptomicsHedgehog pathway analysis in both CD138+ and B-cells obtained from newly diagnosed Multiple Myeloma patients
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-05-31 | E-GEOD-69000 | biostudies-arrayexpress
TranscriptomicsCD138+ expression and genomic profile obtained from newly diagnosed Multiple Myeloma patients up-front treated with VTD induction therapy
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-69029 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data from BM-CD138+, obtained from newly diagnosed Multiple Myeloma patients [response to VTD therapy]
The prime focus of the current therapeutic strategy for Multiple Myeloma (MM) is an early and deep tumour burden reduction; this characterizes and defines the complete response (CR). To date, no description of the characteristics of the plasma cells (PC) prone to achieve CR has been reported. This s...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-69028 | biostudies-arrayexpress
TranscriptomicsExpression data from BM-CD138+, BM B cells and PBL B cells obtained from newly diagnosed Multiple Myeloma patients
The iperactivation of self-renewal mechanisms, like Hedgehog (HH) pathway, which govern the refuel of Multiple Myeloma neoplastic clone, is critical to relapse events. The bulk of current knowledge is mainly based on the CD138+ cells molecular characterization, but in the light of the recent evidenc...
ORGANISM(S): Homo sapiens 
2016-05-31 | E-GEOD-68891 | biostudies-arrayexpress
TranscriptomicsExpression data from BM-CD138+, obtained from newly diagnosed Multiple Myeloma patients [response to VTD therapy]
The prime focus of the current therapeutic strategy for Multiple Myeloma (MM) is an early and deep tumour burden reduction; this characterizes and defines the complete response (CR). To date, no description of the characteristics of the plasma cells (PC) prone to achieve CR has been reported. This s...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-68871 | biostudies-arrayexpress
TranscriptomicsExpression data from CD138+ cells obtained from MM patients at diagnosis
Thalidomide-dexamethasone (TD) combination is an effective induction therapy for newly diagnosed multiple myeloma patients, candidates for subsequent autologous stem cell transplantation (ASCT). Since maximization of tumor response before ASCT may favorably affect the clinical outcomes, we designed ...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-16791 | biostudies-arrayexpress
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