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ProteomicsTetraspanin-based immunocapture for high-depth proteomic profiling of extracellular vesicles from cerebrospinal fluid for biomarker discovery
Due to its proximity to cells of the central nervous system, cerebrospinal fluid (CSF) is an important source of novel biomarkers for neurological diseases. Membrane-bound extracellular vesicles (EVs) are enriched for proteins of intracellular and membrane origin, implicated in the pathogenesis of s...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD061653 | Pride
Cerebrospinal fluid Proteomics Tetraspanin Extracellular vesicle Immunocapture. 
ProteomicsTetraspanin 4 stabilizes membrane swellings and facilitates their maturation into migrasomes
Migrasomes are newly discovered cell organelles forming by local swelling of retraction fibers. The migrasome formation critically depends on tetraspanin proteins present in the retraction fiber membranes and is modulated by the membrane tension and bending rigidity. It remained unknown how and in w...
ORGANISM(S): Homo sapiens (Human) 
2023-01-29 | PXD039664 | Pride
Migrasome Tetraspanin 4 
TranscriptomicsTetraspanin CD63 acts as a pro-metastatic factor via β-catenin stabilization
The tetraspanin CD63 is implicated in pro-metastatic signaling pathways, but so far, it is unclear how CD63 levels affect the tumor cell phenotype. Here, we investigated the effect of CD63 modulation in different metastatic tumor cell lines. In vitro, knock down of CD63 induced a more epithelial-lik...
ORGANISM(S): Homo sapiens 
2015-01-23 | E-GEOD-61957 | biostudies-arrayexpress
TranscriptomicsDifferentiated vs. undifferentiated promyelocytic cell lines (HL-60 and KG-1) and Neutrophiles
We identify the tetraspanin CD82 as the recognition site for xenogeneic endothelial cells independently of Gala1,3-gal structures. We demonstrate that in contrast to undifferentiated cells, differentiated promyelocytic cell lines (HL-60, THP-1 and KG-1) are capable of recognizing xenogeneic porcine...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-43211 | biostudies-arrayexpress
ProteomicsFFPE tumor samples reveals the influences of NET-1 siRNA nanoparticles and sonodynamic therapy on tetraspanin protein involved in HCC
Hepatocellular carcinoma (HCC) poses a severe threat to human health. The NET-1 protein has been proved to be strongly associated with HCC proliferation and metastasis in our previous study. Here, we established and validated NET-1 siRNA nanoparticles system to conduct targeted gene therapy of HCC x...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020763 | Pride
Ultrasound Proteomics Mass spectrometry Tetraspanin protein Hepatocellular carcinoma Sonodynamic therapy 
UnknownTetraspanin CD9 alters cellular trafficking and endocytosis of tetraspanin CD63, affecting CD63 packaging into small extracellular vesicles.
Not available
S-EPMC11919600 | biostudies-literature
UnknownMicroscopic clusters feature the composition of biochemical tetraspanin-assemblies and constitute building-blocks of tetraspanin enriched domains.
Not available
S-EPMC10808221 | biostudies-literature
ProteomicsTetraspanin-6 antagonizes the release of exosomes by stimulating the lysosomal degradation of syntenin and syndecan-4
Exosomes, extracellular vesicles (EV) of endosomal origin, emerge as master regulators of cell-to-cell signaling in physiology and various systemic diseases. Exosomes are highly enriched in tetraspanins (TSPN) and syndecans (SDC), the latter occurring mainly in proteolytically-cleaved form, as membr...
ORGANISM(S): Homo sapiens (Human) 
2020-02-12 | PXD014559 | Pride
Human Lc-msms Exosomes Tetraspanin Gfp-trap Syntenin 
UnknownThe tetraspanin web revisited by super-resolution microscopy.
Not available
S-EPMC4505338 | biostudies-literature
UnknownCrystallization of the human tetraspanin protein CD9.
Not available
S-EPMC6450527 | biostudies-literature
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