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TranscriptomicsHuman liver biopsy of different phases from control to NASH
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Liver samples from morbidly obese patients (N=45) with all stages of NAFLD and controls (N=18) were analysed by array-based DNA methylation and mRNA expression profiling. NAFLD-specific e...
ORGANISM(S): Homo sapiens 
2013-08-08 | E-GEOD-48452 | biostudies-arrayexpress
TranscriptomicsTumor infiltrating IL-33 producing effector-memory CD8+ T cells in resected hepatocellular carcinoma prolong patient survival
Background: IL-33, a cytokine with pleiotropic functions, is elevated in serum of patients with hepatocellular carcinoma (HCC). This study investigated effects of local IL-33 expression in resected HCC on patient survival and on immunological and molecular tumor microenvironment. Methods: Tissue of...
ORGANISM(S): Homo sapiens 
2014-12-08 | E-GEOD-63850 | biostudies-arrayexpress
GenomicsSalt augments macrophage-driven host defense in the skin
Immune cells regulate a hypertonic microenvironment in the skin; however, possible functions of increased skin Na+ concentrations are unknown. We found that Na+ accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania (L.) major as a model...
ORGANISM(S): Mus musculus 
2015-02-26 | E-MTAB-3343 | biostudies-arrayexpress
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