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TranscriptomicsPost-transcriptional generation of miRNA variants by multiple nucleotidyl transferases contributes to miRNA transcriptome complexity (Validation 1)
Modification of microRNA sequences by the 3' addition of nucleotides to generate so-called M-bM-^@M-^\isomiRsM-bM-^@M-^] adds to the complexity of miRNA function, with recent reports showing that 3' modifications can influence miRNA stability and efficiency of target repression. Here we show that th...
ORGANISM(S): synthetic construct 
2011-06-15 | E-GEOD-26916 | biostudies-arrayexpress
TranscriptomicsSystematic design and functional analysis of artificial microRNAs as an approach for multi-gene targeting
Unlike short interfering RNAs (siRNAs), which are commonly designed to repress a single messenger RNA (mRNA) target through perfect base pairing, microRNAs (miRNAs) are endogenous small RNAs that have evolved to concurrently repress multiple mRNA targets through imperfect complementarity. MicroRNA t...
ORGANISM(S): Homo sapiens 
2014-02-28 | E-GEOD-50249 | biostudies-arrayexpress
TranscriptomicsRepertoire of miRNAs in epithelial ovarian cancer determined by next generation sequencing of small RNA cDNA libraries
Background: MicroRNAs (miRNAs) are small regulatory RNAs that are implicated in cancer pathogenesis and have recently shown promise as blood-based biomarkers for cancer detection. Epithelial ovarian cancer is a deadly disease for which improved outcomes could be achieved by successful early detectio...
ORGANISM(S): Homo sapiens 
2009-03-12 | E-GEOD-15190 | biostudies-arrayexpress
TranscriptomicsMicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries
We used massively parallel pyrosequencing to discover and characterize microRNAs (miRNAs) expressed in human embryonic stem cells (hESCs). Sequencing of small RNA cDNA libraries derived from undifferentiated hESC and from isogenic differentiating cultures yielded a total of 425,505 high-quality sequ...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-21722 | biostudies-arrayexpress
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