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GenomicsDNase I hypersensitivity and algorithmic prediction of TF binding in early pancreatic mES directed differentiation
This dataset uses DNase-seq to profile the genome-wide DNase I hypersensitivity of mES and mES-derived cells along an early pancreatic lineage and provides the locations of putative Transcription Factor (TF) binding sites using the PIQ algorithm. DNase-seq takes advantage of the preferential cutting...
ORGANISM(S): Mus musculus 
2014-01-19 | E-GEOD-53776 | biostudies-arrayexpress
TranscriptomicsUnraveling determinants of transcription factor binding outside the core binding site
Binding of transcription factors (TFs) to regulatory sequences is a pivotal step in the control of gene expression. Despite many advances in the characterization of sequence motifs recognized by TFs, our ability to quantitatively predict TF binding to different regulatory sequences is still limited....
ORGANISM(S): synthetic construct 
2015-03-04 | E-GEOD-66143 | biostudies-arrayexpress
TranscriptomicsQuantitative modeling of transcription factor binding specificities using DNA shape
Accurate predictions of the DNA binding specificities of transcription factors (TFs) are necessary for understanding gene regulatory mechanisms. Traditionally, predictive models are built based on nucleotide sequence features. Here, we employed three- dimensional DNA shape information obtained on a ...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-59845 | biostudies-arrayexpress
GenomicsTranscription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites
During cell division, transcription factors (TFs) are removed from chromatin twice, during DNA synthesis, and during condensation of chromosomes. How TFs can efficiently find their sites following these stages has been unclear. Here, we have analyzed the binding pattern of expressed TFs in human col...
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-49402 | biostudies-arrayexpress
GenomicsHigh-resolution mapping of transcription factor binding sites on native chromatin
Sequence-specific DNA-binding proteins including transcription factors (TFs) are key determinants of gene regulation and chromatin architecture. Formaldehyde cross-linking and sonication followed by Chromatin ImmunoPrecipitation (X-ChIP) and sequencing is widely used for genome-wide profiling of pro...
ORGANISM(S): Drosophila melanogaster 
2013-12-14 | E-GEOD-45672 | biostudies-arrayexpress
GenomicsChIP-Seq on Cohesin mutant TF-1 Cell Line
Understanding the binding of GATA2, RUNX1 and SMC3 in RAD21 WT vs. mutant TF-1 Cells We examined GATA2, RUNX1 and SMC3 using ChIP-seq in TF-1 erythroleukemia cells that were transduced with an inducible vector expression WT or mutant (Q592*) RAD21 after 6 days of DOX induction
ORGANISM(S): Homo sapiens 
2015-11-03 | E-GEOD-73207 | biostudies-arrayexpress
GenomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [ChIP-seq].
We used the paradigmatic 'GATA-PU.1 axis’ to explore, at systems-level, dynamic relationships between transcription factor (TF) binding and global gene expression programs as multipotent cells differentiate. We combined global ChIPSeq of GATA1, GATA2 and PU.1 with expression profiling during differe...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-50406 | biostudies-arrayexpress
GenomicsTranscription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites [S-phase/M-phase synchronized cells]
During cell division, transcription factors (TFs) are removed from chromatin twice, during DNA synthesis, and during condensation of chromosomes. How TFs can efficiently find their sites following these stages has been unclear. Here, we have analyzed the binding pattern of expressed TFs in human col...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-51290 | biostudies-arrayexpress
GenomicsTF co-binding to nucleosome arrays
TF co-binding to nucleosome arrays
PRJNA833312 | ENA
TranscriptomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [TC]
An expression time course experiment to investigate gene expression changes during differentiation of multipotential cells over two lineages using the model cell line FDCPmix differentiating towards erytroid and myeloid fates. We used the paradigmatic 'GATA-PU.1 axis’ to explore, at systems-level, d...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-49987 | biostudies-arrayexpress
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