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ProteomicsCD44 acts as a co-receptor to confer cell type-specific enhancement of signaling and regulatory T cell induction by TGM-1, a helminth parasite mimic of TGF
Long-lived parasites evade host immunity through highly evolved molecular strategies. The murine intestinal helminth, Heligmosomoides polygyrus, suppresses the host immune system through release of an immunoregulatory TGF-β mimic, TGM-1, which is a divergent member of the CCP (Sushi) protein family....
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD037799 | Pride
Heligmosomoides polygyrus Tgf- mimic Lymphocyte Convergent evolution Fibroblast Complement control protein 
ProteomicsThe TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding.
The murine helminth parasite Heligmosomoides polygyrus expresses a family of modular proteins which, replicating the functional activity of the immunomodulatory cytokine TGF-β, have been named TGM (TGF-β Μimic). Multiple domains bind to different receptors, including TGF-β receptors TβRI (ALK5) and ...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-15 | PXD048278 | Pride
Immunomodulatory cytokine Helminth worm parasites Tgm (tgf-β mimic) 
ProteomicsDistinct phenotypes induced by acute hypoxia and TGF-β1 in human adult cardiac fibroblasts
Myocardial infarctions cause hypoxic injury to downstream tissue and a consequent fibrotic remodeling process to replace injured tissue with a scar. Scar formation occurs through phases of wound healing in which stimuli such as transforming growth factor-beta (TGF-β) drive cardiac fibroblasts to act...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD051197 | Pride
Hypoxia Transforming growth factor-beta Cardiac fibrosis Hypoxia-inducible factors Myocardial infarction 
GenomicsInduction of stable human FOXP3+ Tregs by a parasite-derived TGF-β mimic
Induction of stable human FOXP3+ Tregs by a parasite-derived TGF-β mimic
PRJNA691165 | ENA
ProteomicsDrosha/Dicer/miR-7/TGF-β2 axis Sustained Acidic Microenvironment-induced Lung Metastasis
Extracellular pH (pHe) is lower in many tumors than in the corresponding normal tissue. Acidic tumor microenvironment has been shown to facilitate epithelial mesenchymal transition (EMT) and tumor metastasis, while the mechanisms underlying tumor acidic microenvironment-induced tumor cell metastasis...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD016524 | Pride
Tumor acidic microenvironment  epithelial-mesenchymal transition  metastasis  microrna-7  tgf-β2 
UnknownA structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.
Not available
S-EPMC5701006 | biostudies-literature
UnknownTGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus.
Not available
S-EPMC5904571 | biostudies-literature
UnknownThe parasite cytokine mimic Hp-TGM potently replicates the regulatory effects of TGF-β on murine CD4+ T cells.
Not available
S-EPMC9214624 | biostudies-literature
UnknownSuppression of airway allergic eosinophilia by Hp-TGM, a helminth mimic of TGF-β.
Not available
S-EPMC9885513 | biostudies-literature
UnknownStructural and functional analysis of the TGF-β mimic, TGM-2: an immunomodulatory helminth protein.
Not available
S-EPMC12923355 | biostudies-literature
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