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MetabolomicsXiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea via TGR5-FAK-RhoA/Rock signaling revealed by integrated metabolomics and proteomics

Irinotecan (CPT-11) is widely used for colorectal cancer treatment, with delayed-onset diarrhea as its primary side effect. Xiao-Chai-Hu-Tang (XCHT) has been clinically observed to alleviate diarrhea, but its mechanisms remain unclear. This study aimed to explore the underlying regulatory mechani...

2025-09-03 | MTBLS12931 | MetaboLights
TranscriptomicsProtective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling
1.1 Introduction Cardiac fibrosis occurs in a wide range of cardiac diseases and is characterised by the transdifferentiation of cardiac fibroblasts into myofibroblasts these cells produce large quantities of extracellular matrix, resulting in myocardial scar. The profibrotic process is m...
ORGANISM(S): Homo sapiens 
2024-11-30 | E-MTAB-14602 | biostudies-arrayexpress
TranscriptomicsBile acid receptor Tgr5 prevents macrophage hyperinflammation during bacterial sepsis through metabolic and epigenetic silencing
Tgr5 is a membrane-bound bile acid receptor that negatively regulates immune cells, although the molecular mechanisms behind this observation remain elusive. Here we report that Tgr5 is upregulated in macrophages during stimulation with Listeria monocytogenes and that Tgr5-deficient macrophages are ...
ORGANISM(S): Mus musculus 
2025-10-03 | GSE309415 | GEO
TranscriptomicsThe G protein-coupled bile acid receptor TGR5 (Gpbar1) modulates endothelin-1 signalling in liver
TGR5 (Gpbar1) is a G protein-coupled receptor responsive to bile acids (BAs), which is expressed in different non-parenchymal cells of the liver, including biliary epithelial cells, liver-resident macrophages, sinusoidal endothelial cells (LSECs) and activated hepatic stellate cells (HSCs). Mice wit...
ORGANISM(S): Mus musculus 
2019-11-19 | GSE139075 | GEO
GenomicsBile acid receptor Tgr5 prevents macrophage hyperinflammation during bacterial sepsis through metabolic and epigenetic silencing
Bile acid receptor Tgr5 prevents macrophage hyperinflammation during bacterial sepsis through metabolic and epigenetic silencing
PRJNA1336054 | ENA
GenomicsThe G protein-coupled bile acid receptor TGR5 (Gpbar1) modulates endothelin-1 signalling in liver
The G protein-coupled bile acid receptor TGR5 (Gpbar1) modulates endothelin-1 signalling in liver
PRJNA578280 | ENA
TranscriptomicsDownregulation of TGR5 (GPBAR1) in biliary epithelial cells is characteristic of sclerosing cholangitis and may contribute to disease pathogenesis
Primary sclerosing cholangitis (PSC) is characterized by chronic inflammation and progressive fibrosis of the biliary tree. The bile acid receptor TGR5 is found on biliary epithelial cells (BECs), where it promotes secretion, proliferation and tight junction integrity. Thus, we speculated that chang...
ORGANISM(S): Mus musculus 
2021-03-12 | GSE168758 | GEO
TranscriptomicsDCA-TGR5 signaling activation alleviates inflammatory response and improves cardiac function in myocardial infarction
The progression of myocardial infarction (MI) involves multiple metabolic disorders. Bile acid metabolites have been increasingly recognized as pleiotropic signalling molecules that regulate multiple cardiovascular functions. G protein-coupled bile acid receptor (TGR5) is one of the receptors sensin...
ORGANISM(S): Mus musculus 
2020-09-24 | GSE158415 | GEO
GenomicsDCA-TGR5 signaling activation alleviates inflammatory response and improves cardiac function in myocardial infarction
DCA-TGR5 signaling activation alleviates inflammatory response and improves cardiac function in myocardial infarction
PRJNA665198 | ENA
Genomics
RNA-seq of LPS-primed TGR5+/+ BMDCs and TGR5-/- BMDCs treated with LCA
PRJNA760665 | ENA
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