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TranscriptomicsCXCR3+ Treg cells suppress Th1-immune responses through expression of the co-inhibitory receptors CD85k and Lag-3
CD4+Foxp3+ Treg cells are essential for maintaining self-tolerance and preventing excessive immune responses. In the context of Th1 immune responses, co-expression of the Th1 transcription factor T-bet with Foxp3 is essential for Treg cells to control Th1 responses. T-bet-dependent expression of CXC...
ORGANISM(S): Mus musculus 
2018-06-30 | E-MTAB-6156 | biostudies-arrayexpress
TranscriptomicsTrpm4-induced gene expression changes in Th1 and Th2 cells
T helper cell subsets have unique calcium (Ca2+) signals when activated with identical stimuli. The regulation of these Ca2+ signals and their correlation to the biological function of each T cell subset remains unclear. Trpm4 is a Ca2+-activated cation channel that we found is expressed at higher...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-21996 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of early differentiating Tfh vs Th1 cells
Comparison of transcriptome between early Tfh vs. early Th1 cells Blimp-1-YFP LCMV gp specific TCRtg Smarta cells were transferred into B6 mice, which were then infected with LCMV Armstrong. On day 3 after infection, splenocytes were stained to sort Blimp-1-YFP+IL-2Ra+ Th1 cells or Blimp-1-YFP-IL-2R...
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-67334 | biostudies-arrayexpress
TranscriptomicsInflammation driven by tumor-specific Th1 cells protects against B-cell cancer
The immune system can both promote and suppress cancer. Chronic inflammation and proinflammatory cytokines such as interleukin (IL)-1 and IL-6 are considered tumor-promoting. In contrast, the exact nature of protective antitumor immunity remains obscure. In this study, we have quantified locally sec...
ORGANISM(S): Mus musculus 
2011-03-15 | E-GEOD-26912 | biostudies-arrayexpress
ProteomicsReference proteome of highly purified human Th1 cells reveals strong effects on metabolism and protein ubiquitination upon differentiation
The differentiation of human CD4+ T cells into different subtypes of T helper cells and regulatory T cells is crucial for an appropriate immunological response. Among all subtypes Th1 cells are the most prominent specific cell type, representing about 50% of all lymphocytes. So far most global prote...
ORGANISM(S): Homo sapiens (Human) 
2015-10-13 | PXD001066 | Pride
Th1 cells Cd4+ Human Lc-ms/ms 
TranscriptomicsIdentification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGFbeta [Affymetrix]
IL-4 plays an important role in the induction of Th2 and Th9 cells as well as in the inhibition of Th1 cell generation. We herein show that a combination of IL-4 and TGFbeta augment the development of Th1 cells that express CD103 (CD103+ Th1 cells) if IFNgamma is present. The T-box containing tran...
ORGANISM(S): Mus musculus 
2012-03-17 | E-GEOD-36520 | biostudies-arrayexpress
GenomicsEarly T-helper 1 Differentiation Is Marked by A Follicular Helper-like Transition: Differential Roles of STAT4 and T-bet
Follicular helper T (Tfh) cells comprise an important subset of helper T cells; however, their relationship with other helper lineages is incompletely understood. Herein, we show IL-12 acting via signal transducer and activator of transcription 4 (STAT4) induced both Il21 and Bcl6 genes, generating ...
ORGANISM(S): Mus musculus 
2011-12-27 | E-GEOD-33802 | biostudies-arrayexpress
TranscriptomicsThe Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses
T-bet is a critical transcription factor for T helper 1 (Th1) cell differentiation. To study the regulation and functions of T-bet, we developed a T-bet-ZsGreen reporter mouse strain, in which GFP faithfully reflects the expression of T-bet. By using this tool, we report that signals elicited by IL...
ORGANISM(S): Mus musculus 
2012-10-04 | E-GEOD-38808 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Th cells induced to polarize to Th1 or Th2 direction in the presence or absence of TGFbeta
Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to ...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-2770 | biostudies-arrayexpress
TranscriptomicsGeneration and purification of Th1 and Th2 effector and memory CD4+ T cells
Naïve CD4+ T cells were isolated from spleen of AND TcR transgenic/green fluorescence protein (GFP) transgenic mice (Kaye et al., Nature 1989;341:746, Wright et al, Blood 2001;97:2278) that recognize a peptide of pigeon cytochrome C in the context of I-Ek and express CD44lo, CD62Lhi, CD45RBhi, and ...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-8352 | biostudies-arrayexpress
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