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MetabolomicsImpact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository

INTRODUCTION: Acute lymphoblastic leukemia (ALL) is among the most common cancers in children. With improvements in combination chemotherapy regimens, the overall survival has increased to over 90%. However, the current challenge is to mitigate adverse events resulting from the c...

2021-08-12 | MTBLS2394 | MetaboLights
MetabolomicsA Pilot Characterization of the Human Chronobiome
Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results in cardio-metabolic, immunological and neurological dysfunction; circadian misalignment using forced desynchrony increases cardiovascular risk factors in humans. Here we integrated data ...
2018-05-16 | MTBLS656 | MetaboLights
TranscriptomicsCXCL4 induces a unique transcriptome in monocyte-derived macrophages
Human blood monocytes were differentiated over six days with either 100 ng/ml M-CSF or 1 umol/l CXCL4 In atherosclerotic arteries, blood monocytes differentiate to macrophages in the presence of growth factors like macrophage colony-stimulation factor (MCSF) and chemokines like platelet factor 4 (CX...
ORGANISM(S): Homo sapiens 
2010-03-07 | E-GEOD-20484 | biostudies-arrayexpress
UnknownCarbon nitride-TiO2 hybrid modified with hydrogenase for visible light driven hydrogen production.
Not available
S-EPMC5512016 | biostudies-literature
UnknownMid-Holocene expansion of the Indian Ocean warm pool documented in coral Sr/Ca records from Kenya.
Not available
S-EPMC9840608 | biostudies-literature
TranscriptomicsTranscription profiling of S. pombe reveals Cyclin dependent kinase inhibits re-initiation of a normal S-phase program during G2
To achieve faithful replication of the genome once in each cell cycle, re-initiation of S-phase is prevented in G2 and origins are restricted from re-firing within S-phase. We have investigated the block to re-replication during G2 in fission yeast. The DNA synthesis that occurs when G2/M cyclin d...
ORGANISM(S): Schizosaccharomyces pombe 
2009-05-13 | E-MTAB-105 | biostudies-arrayexpress
TranscriptomicsHuman 32 MPSS samples
This series represents a very deep survey of all transcripts expressed in a wide range of human tissues and cells by Massively Parallel Signature Sequencing (MPSS). These datasets have been generated and donated to the scientific community by Lynx Therapeutics, Inc in Hayward, CA. The data contained...
ORGANISM(S): Homo sapiens 
2005-11-29 | GSE1747 | GEO
GenomicsDNA methylation changes are a late event in Acute Promyelocytic Leukemia and coincide with loss of transcription factor binding (sequencing)
The origin of aberrant DNA methylation in cancer remains largely unknown. In this study, we elucidated the DNA methylome in primary Acute Promyelocytic Leukemia (APL) and the role of PML-RARa in establishing these patterns. APL patients showed increased genome-wide DNA methylation with higher variab...
ORGANISM(S): Homo sapiens 
2012-11-08 | E-GEOD-42044 | biostudies-arrayexpress
ProteomicsH.sapiens - Cell line, Pancreatic metastatic, SC (Kim,mcp,2014)
abundance based on Spectral counting, Pancreatic_metastatic, Interaction consistency score: 21.5, Coverage: 32
ORGANISM(S): 9606 
2014-00-00 | 4148541313 | PAXDB
TranscriptomicsDevelopmentally Abnormal Human Embryos Trigger a Maternal ER Stress Response
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study were to compare signals from competent and abnormal human embryos impacted differently on the expression of endometrial receptivity genes in mouse uteri using transcripto...
ORGANISM(S): Mus musculus 
2014-02-11 | E-GEOD-47019 | biostudies-arrayexpress
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