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ProteomicsQuantitaQuantitative proteomic analysis of β-cells response to thapsigargin and rotenone uncovers key pathways of rat β-cell dysfunction tive proteomic analysis of β-cells response to thapsigargin and rotenone uncovers key pathways of rat β-cell dysfunction
We designed a TMT peptide labeling-based quantitative proteomics strategy to achieve a high-accuracy analysis of proteomic changes in response to ER stress and mitochondria stress on INS-1 cells under three different culture conditions: control (Cont), rotenone (Rot), and thapsigargin (Tpg), each wi...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-07-20 | PXD030711 | Pride
Endoplasmic reticulum (er) stress  mitochondria stress  quantitative proteomics  tmtpro  ins-1 beta cells Cells  metascape 
GenomicsCG methylated microarrays identify novel methylated sequence bound by the CEBPB|ATF4 heterodimer that are active in vivo
To evaluate the effect of CG methylation on DNA binding of sequence-specific B-ZIP transcription factors (TFs) in a high-throughput manner, we enzymatically methylated the cytosine in the CG dinucleotide on protein binding microarrays. Using this novel technology, we show that CG methylation enhanc...
ORGANISM(S): Mus musculus 
2013-03-08 | E-GEOD-44942 | biostudies-arrayexpress
TranscriptomicsNext Generation Deep Sequencing Facilitates Quantitative Analysis of microRNA affected by thapsigargin treatment
Purpose: microRNA profiles were generated from NIH-3T3 cells control and thapsigargin treated, in duplicate. The goal of this study was to compare microRNA profiles of untreated and thapsigargin treated NIH-3T3 fibroblast cells. Methods: NIH-3T3 cells were grown to confluency and either untreated or...
ORGANISM(S): Mus musculus 
2014-06-15 | E-GEOD-57138 | biostudies-arrayexpress
TranscriptomicsINS1-EGFP-L10a stable cell lines treated with Thapsigargin
INS1-EGFP-L10a stable cell lines were induced with Doxycycline (Dox) for 24 hours, then either untreated or treated for 30 minutes with 1uM Thapsigargin to induce ER stress. Total RNA was purified with Trizol, and RIP RNA samples were extracted by immunoaffinity purification using an EGFP antibody ...
ORGANISM(S): Rattus norvegicus 
2012-09-01 | E-GEOD-39212 | biostudies-arrayexpress
GenomicsTranscriptome alteration in Nrf2 mutant developing oligodendrocytes treated with interferon gamma and thapsigargin in comparison with wild-type developing oligodendrocytes treated with interferon gamma and thapsigargin
Transcriptome alteration in Nrf2 mutant developing oligodendrocytes treated with interferon gamma and thapsigargin in comparison with wild-type developing oligodendrocytes treated with interferon gamma and thapsigargin
PRJNA678719 | ENA
GenomicsInduction of ER stress in SHSY5Y human neuroblastoma cells by thapsigargin treatment
Induction of ER stress in SHSY5Y human neuroblastoma cells by thapsigargin treatment
PRJNA1107564 | ENA
GenomicsThapsigargin inhibition of coronavirus PHEV replication by Ca2+ mediated metabolic reprogramming
Thapsigargin inhibition of coronavirus PHEV replication by Ca2+ mediated metabolic reprogramming
PRJNA1032947 | ENA
UnknownThapsigargin-From Traditional Medicine to Anticancer Drug.
Not available
S-EPMC7792614 | biostudies-literature
GenomicsExpression data from podocytes cultured in vitro treated with thapsigargin +/- forskolin
Expression data from podocytes cultured in vitro treated with thapsigargin +/- forskolin
PRJNA415811 | ENA
GenomicsGene expression changes in human neuroglioma cell line H4 upon stress induction with sorbitol or thapsigargin
Gene expression changes in human neuroglioma cell line H4 upon stress induction with sorbitol or thapsigargin
PRJNA1470642 | ENA
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