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MetabolomicsAutomated Label-free Quantification of Metabolites from Liquid Chromatography–Mass Spectrometry Data (Plasma)

Liquid chromatography coupled to mass spectrometry (LC-MS) has become a standard technology in metabolomics. In particular, label-free quantification based on LC-MS is easily amenable to large-scale studies and thus well suited to clinical metabolomics. Large-scale studies, however, require autom...

2015-12-16 | MTBLS234 | MetaboLights
TranscriptomicsTranscription profiling of Clostridium acetobutylicum during acidogenesis and solventogenesis
Clostridium acetobutylicum is characterized by its acetone-butanol (AB) fermentation which
can be reproducibly established under continuous grow conditions in a chemostat.
At pH 5.7 cells show typical acidogenic metabolism and mainly produce the acids
acetate and butyrate. After lowering...
ORGANISM(S): Clostridium acetobutylicum 
2010-11-10 | E-MEXP-2503 | biostudies-arrayexpress
TranscriptomicsA transcriptional study of acidogenic chemostat cells of Clostridium acetobutylicum following a single n-butanol pulse
In this study the transcriptional behavior of the natural solvent producing bacterium Clostridium acetobutylicum was investigated following n-butanol stress using DNA microarray analysis. Therefore, a phosphate-limited chemostat culture was established and n-butanol stress (0.9%) was added to acidog...
ORGANISM(S): Clostridium acetobutylicum 
2012-04-30 | E-MEXP-3264 | biostudies-arrayexpress
TranscriptomicsA transcriptional study of acidogenic chemostat cells of Clostridium acetobutylicum following a single n-butanol pulse_Exp2
In this study the transcriptional behavior of the natural solvent producing bacterium Clostridium acetobutylicum was investigated following n butanol stress using DNA microarray analysis. Therefore, a phosphate-limited chemostat culture was established and n-butanol stress (0.9%) was added to acidog...
ORGANISM(S): Clostridium acetobutylicum 
2012-04-30 | E-MEXP-3265 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptional changes of Clostridium acetobutylicum cultures with increased butanol-acetone ratios
Artificial electron carriers have been widely used to shift the solvent ratio towards butanol in acetone-butanol-ethanol (ABE) fermentation of solventogenic clostridia according to decreased hydrogen production. In this study, first insights on the molecular level were gained to explore the effect o...
ORGANISM(S): Clostridium acetobutylicum 
2012-03-31 | E-MEXP-3417 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of primary rat hepatocyte model toxicology system dosed with carbon tetrachloride using three starting qualities of RNA to evaluate impact on the quality of hybridization signals on Agilent Platform
Array data from a primary rat hepatocyte model toxicology system dosed with carbon tetrachloride has been produced on Agilent and Codelink microarray platforms using three starting qualities of RNA (high (RIN: 9.0), medium (RIN: 5.0) and low (RIN: 2.5) quality, assessed by RIN number).
ORGANISM(S): Rattus norvegicus 
2007-11-01 | E-LGCL-7 | biostudies-arrayexpress
TranscriptomicsGenome-associated RNA Polymerase II includes the dissociable Rpb4/7 subcomplex
Yeast RNA polymerase (Pol) II consists of a ten-subunit core enzyme and the Rpb4/7 subcomplex, which is dispensable for catalytic activity and dissociates in vitro. To investigate whether Rpb4/7 is an integral part of DNA-associated Pol II in vivo, we used chromatin immuno-precipitation coupled to h...
ORGANISM(S): Saccharomyces cerevisiae 
2008-07-29 | E-GEOD-12060 | biostudies-arrayexpress
TranscriptomicsIntegrated mutation, copy number and expression profiling in resectable non-small cell lung cancer
Study aims: to identify critical genes involved in non-small cell lung cancer (NSCLC) pathogenesis that may lead to a more complete understanding of this disease and identify novel molecular targets for use in the development of more effective therapies. Methods: Both transcriptional and genomic pro...
ORGANISM(S): Homo sapiens 
2010-11-27 | E-GEOD-25326 | biostudies-arrayexpress
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