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MetabolomicsGut microbiota and fermentation-derived branched chain hydroxy acids mediate health benefits of yogurt consumption in obese mice
Meta-analyses suggest that yogurt consumption reduces type 2 diabetes incidence in humans, but the molecular basis of these observations remains unknown. Here we show that dietary yogurt intake preserves whole-body glucose homeostasis and prevents hepatic insulin resistance and liver steatosis in a ...
2022-02-03 | MTBLS442 | MetaboLights
GenomicsMapping of Ikaros and RBPJ binding sites in the mouse T cell leukemia cell line T29
The transcription factor Ikaros represses Notch signaling. Since Ikaros and Notch treanscriptional mediator RBPJ both recognize sequences that contain the same core TGGGAA motif, it was hypothesized that Ikaros represses Notch signaling by targeting Notch response elements and competing with RBPJ fo...
ORGANISM(S): Mus musculus 
2014-04-02 | E-GEOD-46119 | biostudies-arrayexpress
GenomicsMapping of Notch1 binding sites in a mouse immature T cell line
We used an immature mouse T cell line engineered to express a biotinylated form of the cleaved form of Notch1 (ICN1). ICN1-bound sites were precipitated with streptavidin-coated beads and subjected to ChIP-sequencing. Beko cells correspond to a spontaneous T lymphoma immature cell line derived from ...
ORGANISM(S): Mus musculus 
2014-04-02 | E-GEOD-46114 | biostudies-arrayexpress
TranscriptomicsTranscripts coding MHC I-associated peptides are enriched in microRNA-binding sites
MHC I-peptides (MIPs) play an essential role in normal homeostasis and diverse pathological conditions. MIPs derive mainly from defective ribosomal products (DRiPs), a subset of nascent proteins that fail to achieve a proper conformation and whose physical nature remains elusive. We used high-throug...
ORGANISM(S): Homo sapiens 
2012-03-25 | E-GEOD-35319 | biostudies-arrayexpress
UnknownImmunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database.
Not available
S-EPMC5998562 | biostudies-literature
UnknownIdentifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database.
Not available
S-EPMC6203969 | biostudies-literature
UnknownProtecting stable biological nomenclatural systems enables universal communication: A collective international appeal.
Not available
S-EPMC11328142 | biostudies-literature
UnknownIntravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials.
Not available
S-EPMC10600726 | biostudies-literature
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