Sort   by:  
 Page size 
UnknownThe lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP.
Not available
S-EPMC6819133 | biostudies-literature
TranscriptomicsTranscription profiling of control and catalase-deficient Arabidopsis (Arabidopsis thaliana) plants
In plants, reactive oxygen species and, more particularly, hydrogen peroxide (H2O2) play a dual role as toxic by-products of normal cell metabolism and as regulatory molecules in stress perception and signal transduction. Peroxisomal catalases are an important sink for photorespiratory H2O2. Using A...
ORGANISM(S): Arabidopsis thaliana 
2005-10-11 | E-MEXP-449 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of patient-derived COL2A1-mutant chondrogenic urine-derived stem cells against unaffected controls
COL2A1-associated skeletal dysplasias and growth disorders affect cartilage extracellular matrix and endochondral growth, but patient growth-plate tissue is largely inaccessible, limiting non-invasive modelling of disease- and growth-factor-responsive molecular programs. Here, we generated chondroge...
ORGANISM(S): Homo sapiens 
2026-09-30 | E-MTAB-17279 | biostudies-arrayexpress
TranscriptomicsSingle-Cell RNA Sequencing of chondrogenically induced urine-derived stem/stromal cells from patients with COL2A1 variants under control and IGF1-treated conditions
COL2A1-associated skeletal dysplasias and growth disorders affect cartilage extracellular matrix and endochondral growth, but patient growth-plate tissue is largely inaccessible, limiting non-invasive modelling of disease- and growth-factor-responsive molecular programs. Here, we generated chondroge...
ORGANISM(S): Homo sapiens 
2026-09-30 | E-MTAB-17280 | biostudies-arrayexpress
ProteomicsTargeted Proteomics Reveals Quantitative Differences in Low Abundance Glycosyltransferases of Patients with Congenital Disorders of Glycosylation
Protein glycosylation is an essential posttranslational modification in all domains of life. Its impairment in human can result in severe diseases named Congenital Disorders of Glycosylation (CDGs). Most of the glycosyltransferases (GTs) responsible for proper glycosylation are polytopic membrane p...
ORGANISM(S): Homo Sapiens 
2024-01-30 | PXD048072 | panorama
MetabolomicsUntargeted Metabolomics Reveals Molecular Effects of Ketogenic Diet on Healthy and Tumor Xenograft Mouse Models
The application of ketogenic diet (KD) (high fat/low carbohydrate/adequate protein) as an auxiliary cancer therapy is a field of growing attention. KD provides sufficient energy supply for healthy cells, while possibly impairing energy production in highly glycolytic tumor cells. Moreover, KD regula...
2019-10-08 | MTBLS1066 | MetaboLights
UnknownMutations in CDK5RAP2 cause Seckel syndrome.
Not available
S-EPMC4585455 | biostudies-literature
ProteomicsAffinity purification mass spectrometry analysis of SARS-CoV-2 and SARS-CoV proteins in A549 cells
To determine the cellular binding partners of SARS-CoV-2 and SARS-CoV, A459 cells were transduced with lentiviruses expressing HA-tagged virus proteins and subjected to affinity purification mass spectrometry analysis.
ORGANISM(S): Homo sapiens (Human) 
2020-07-14 | PXD020222 | Pride
Sars-cov-2  sars-cov  apms  a549 cells 
UnknownGrand Challenges in global eye health: a global prioritisation process using Delphi method.
Not available
S-EPMC8732284 | biostudies-literature
ProteomicsTruncated N-glycans destabilize POMT1 and POMT2 but do not limit cellular O-mannosylation in HEK293 cells
Protein O-mannosylation is initiated by the ER-resident enzymes POMT1 and POMT2, both of which carry multiple N-glycans essential for proper folding and activity. Although congenital disorders of glycosylation type I (CDG-I) disrupt the early N-glycosylation process, their impact on POMT biogenesis ...
ORGANISM(S): Homo Sapiens 
PXD073179 | panorama
Sort   by:  
 Page size