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MetabolomicsIsotope Labeled Reactivity-Based Metabolomics Reveal Cysteine as a Potent In Vivo Scavenger of Lactoylglutathione

Metabolite adducts are increasingly being recognized as important intermediates in cellular metabolism and as circulating messengers. Methylglyoxal (MG) is a highly reactive metabolite involved in diabetes and aging, via formation of a wide variety of protein adducts. Though new types of protein ...

2025-04-29 | MTBLS6287 | MetaboLights
UnknownGeneration of a humanized afucosylated BAFF-R antibody with broad activity against human B-cell malignancies.
Not available
S-EPMC10027513 | biostudies-literature
UnknownIntrogression of Two Broad-Spectrum Late Blight Resistance Genes, Rpi-Blb1 and Rpi-Blb3, From Solanum bulbocastanum Dun Plus Race-Specific R Genes Into Potato Pre-breeding Lines.
Not available
S-EPMC7326066 | biostudies-literature
TranscriptomicsBeta-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/beta-catenin signaling
To validate the suitability of two commonly used colorectal cancer cell lines, DLD1 and SW480, as model systems to study colorectal carcinogenesis, we treated these cell lines with beta-catenin siRNA and identified beta-catenin target genes using DNA microarrays. The list of identified target genes ...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-44097 | biostudies-arrayexpress
TranscriptomicsRNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates Fasudil as an anti-leukemic drug.
Acute myeloid leukemia (AML) is characterized by a marked genetic heterogeneity, which complicates the development of novel therapeutics. The delineation of pathways essential within the patient-individual mutational background might overcome this limitation and facilitate personalized treatment. We...
ORGANISM(S): Homo sapiens 
2015-05-16 | E-GEOD-68925 | biostudies-arrayexpress
UnknownReproducibility of consecutive automated telemetric noctodiurnal IOP profiles as determined by an intraocular implant.
Not available
S-EPMC11503138 | biostudies-literature
UnknownNon-host Resistance Induced by the Xanthomonas Effector XopQ Is Widespread within the Genus Nicotiana and Functionally Depends on EDS1.
Not available
S-EPMC5127841 | biostudies-literature
UnknownCAM/TMA-DPH as a promising alternative to SYTO9/PI for cell viability assessment in bacterial biofilms.
Not available
S-EPMC11790577 | biostudies-literature
UnknownDiagnostic accuracy and confounders of vagus nerve ultrasound in amyotrophic lateral sclerosis-a single-center case series and pooled individual patient data meta-analysis.
Not available
S-EPMC11377580 | biostudies-literature
UnknownAssessment of the effect of physical activity on intraocular pressure using a novel implanted telemetric pressure sensor.
Not available
S-EPMC12505109 | biostudies-literature
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