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TranscriptomicsSingle-cell chromosomal imbalances detection by array CGH
In this study, we extend array CGH technology by making the accurate detection of segmental aneusomies possible from a single lymphoblast and fibroblast following Phi29 DNA polymerase amplification Array CGH experiments were performed on two segmental aneusomic cell lines derived from patients. As a...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4244 | biostudies-arrayexpress
TranscriptomicsSingle-cell aneuploidy detection by array CGH
In this study, we extend array CGH technology by making the accurate detection of chromosomal imbalances possible from a single fibroblast and blastomere following Phi29 DNA polymerase amplification. Firstly, array CGH experiments were performed on four different fibroblast cell lines, derived from ...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-3642 | biostudies-arrayexpress
GenomicsEpigenetic regulation and transcriptional repression by Tet1 in the early post-implantation mouse embryo: ChIP seq
The mammalian TET dioxygenases contribute to global waves of DNA demethylation in the zygote and in primordial germ cells, but their involvement during de novo DNA methylation at peri/post-implantation development is unknown. Here, we show novel physiological functions of Tet1 in the pre-primitive s...
ORGANISM(S): Mus musculus 
2017-05-15 | E-MTAB-5562 | biostudies-arrayexpress
GenomicsExomes of High-risk Prostate cancer
DNA extracted from tumoral tissue of 39 patients was used for exome sequencing. As a comparison, DNA extracted from blood was used as a non-tumoral control. DNA was captured using the EZ SeqCap v3 exome kit from Roche and sequenced using an Illumina HiSeq instrument.
EGAS00001001015 | EGA
Genomicsena-DATASET-VIB-13-03-2012-14:05:46:504-2 - samples
Tumor sample of a serious ovarian carcinoma
EGAD00001000139 | EGA
GenomicsOvarian & matched normal (Genotypes) - samples
Ovarian & matched normal (Genotypes)
EGAD00010000220 | EGA
Genomicsena-DATASET-VIB-13-03-2012-14:07:27:404-3 - samples
Blood sample of serious ovarian carcinoma patient
EGAD00001000140 | EGA
Genomicsena-DATASET-VIB-29-07-2013-12:55:51:690-38 - samples
DNA replication errors occurring in mismatch repair (MMR) deficient cells persist as mismatch mutations and predispose to a range of tumors. Here, we sequenced the first whole-genomes from MMR-deficient endometrial tumors.
EGAD00001000641 | EGA
GenomicsComplete Genomics paired end sequencing; Ovarian cancer
We sequenced the genomes from a monozygotic twin discordant for schizophrenia and a tumor-normal pair of an ovarian cancer patient. Using whole-genome twin data to discriminate between correctly identified single nucleotide variants (SNVs) and errors a strategy for the accurate detection of SNVs was...
EGAS00001000158 | EGA
GenomicsSignatures of mismatch repair deficiency in cancer genomes
DNA replication errors occurring in mismatch repair (MMR) deficient cells persist as mismatch mutations and predispose to a range of tumors. Here, we sequenced the first whole-genomes from MMR-deficient tumors and observed that mutation rates were drastically increased relative to MMR-proficient end...
EGAS00001000182 | EGA
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