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ProteomicsCocaine and Environmental Enrichment Proteomics Study of Rat Nucleus Accumbens
Prior research demonstrated that environmental enrichment creates individual differences in behavior leading to a protective addiction phenotype in rats. Understanding the mechanisms underlying this phenotype will guide selection of targets for much-needed novel pharmacotherapeutics. The current stu...
ORGANISM(S): Rattus norvegicus (Rat) 
2014-07-22 | PXD000990 | Pride
Rat Brain Nucleus accumbens Lc-ms/ms Label-free quantification 
TranscriptomicsThe G protein-coupled pH-sensing receptor OGR1 is a regulator of intestinal inflammation
OGR1 is a pH sensing G protein-coupled receptor involved in intestinal homeostasis and inflammation. Up-regulation of genes, mediated by OGR1, in response to extracellular acidification were enriched for inflammation, immune response, actin cytoskeleton and cell adhesion pathways. Microarray profili...
ORGANISM(S): Mus musculus 
2015-04-12 | E-GEOD-60295 | biostudies-arrayexpress
TranscriptomicsAddition of IL-6 inhibition to standard GVHD prophylaxis to prevent GVHD after allogeneic stem cell transplantation
BACKGROUND - IL-6 mediates graft-versus-host disease (GVHD) in experimental allogeneic stem cell transplantation (alloSCT) and is an attractive therapeutic target. METHODS - A registered phase I/II study (ACTRN12612000726853) of IL-6 receptor (IL-6R) neutralizing antibody administration on day -1 to...
ORGANISM(S): Homo sapiens 
2014-09-09 | E-GEOD-61201 | biostudies-arrayexpress
UnknownIdentification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
Not available
S-EPMC5612337 | biostudies-literature
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