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GenomicsGenome wide localization of Activation induced cytidine deaminase (AID), Spt5, and RNA Polymerase II (PolII) in mouse
Activation induced cytidine deaminase (AID) initiates antibody gene diversification by creating U:G mismatches. However, AID is not specific for antibody genes. Off-target lesions can activate oncogenes or cause chromosome translocations. Despite its importance in these key transactions little is kn...
ORGANISM(S): Mus musculus 
2010-10-05 | E-GEOD-24178 | biostudies-arrayexpress
MetabolomicsPREDICT: untargeted metabolomic profiling in a Brassica napus (canola) breeding population by GC-MS

Genome-wide association studies (GWAS) identified thousands of genetic loci associated with complex plant traits, including many traits of agronomical importance. However, functional interpretation of GWAS results remains challenging because of large candidate regions due to linkage disequilibriu...

2023-11-20 | MTBLS8056 | MetaboLights
UnknownRandomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer.
Not available
S-EPMC4878106 | biostudies-literature
TranscriptomicsTranscriptome Analysis of Human Diabetic Kidney Disease (Control Glomeruli vs. Control Tubuli)
We identified 1,700 differentially expressed probesets in DKD glomeruli and 1,831 in diabetic tubuli; 330 probesets were commonly differentially expressed in both compartments. The canonical complement signaling pathway was determined to be statistically differentially regulated in both DKD glomerul...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-30566 | biostudies-arrayexpress
ProteomicsApplication of carbohydrate arrays coupled with mass spectrometry to detect activity of plant-polysaccharide degradative enzymes from the fungus Aspergillus niger
Renewables-based biotechnology depends on enzymes to degrade plant lignocellulose to simple sugars that are converted to fuels or high-value products. Identification and characterization of such lignocellulose degradative enzymes could be fast-tracked by availability of an enzyme activity measuremen...
ORGANISM(S): Aspergillus niger 
2018-10-26 | PXD005699 | Pride
Cazymes Lignocellulose Aspergillus niger Plant-polysaccharide degrading enzymes 
TranscriptomicsTranscriptome Analysis of Human Diabetic Kidney Disease (DKD Glomeruli vs. Control Glomeruli)
We identified 1,700 differentially expressed probesets in DKD glomeruli and 1,831 in diabetic tubuli; 330 probesets were commonly differentially expressed in both compartments. The canonical complement signaling pathway was determined to be statistically differentially regulated in both DKD glomerul...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-30528 | biostudies-arrayexpress
TranscriptomicsTranscriptome Analysis of Human Diabetic Kidney Disease (DKD Tubuli vs. Control Tubuli)
We identified 1,700 differentially expressed probesets in DKD glomeruli and 1,831 in diabetic tubuli; 330 probesets were commonly differentially expressed in both compartments. The canonical complement signaling pathway was determined to be statistically differentially regulated in both DKD glomerul...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-30529 | biostudies-arrayexpress
TranscriptomicsTranscriptome Analysis of Human Diabetic Kidney Disease
This SuperSeries is composed of the following subset Series: GSE30528: Transcriptome Analysis of Human Diabetic Kidney Disease (DKD Glomeruli vs. Control Glomeruli) GSE30529: Transcriptome Analysis of Human Diabetic Kidney Disease (DKD Tubuli vs. Control Tubuli) GSE30566: Transcriptome Analysis of H...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-30122 | biostudies-arrayexpress
TranscriptomicsLeishmania major promastigote ChIP-chip: TBP, SNAP50, acetylH3
The goal of this study is to identify likely sites of polycistronic transcription initiation in a kinetoplastid parasite. Peaks in histone H3 acetylations were found to mark these likely sites, with TBP and SNAP50 enriched upstream of these acetylation peaks. Acetylation peaks are greater in rapid...
ORGANISM(S): Leishmania major 
2010-05-16 | E-GEOD-13415 | biostudies-arrayexpress
UnknownExemestane versus anastrozole in postmenopausal women with early breast cancer: NCIC CTG MA.27--a randomized controlled phase III trial.
Not available
S-EPMC3612593 | biostudies-literature
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