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TranscriptomicsTranscription profiling of yeast under conditions of ammonium, L-alanine or L-glutamine limitation
Response of Saccharomyces cerevisiae to Ammonium, L-alanine, or L-glutamine Limitation. The protrotophic laboratory strain CEN.PK113-7D (MAT a) was grown in laboratory fermentors with a working volume of 1 litre at dilution rate (D) of 0.20 per hour (in triplicate for each nitrogen limited condition...
ORGANISM(S): Saccharomyces cerevisiae 
2006-06-13 | E-MEXP-724 | biostudies-arrayexpress
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
TranscriptomicsCooperative Epigenetic Modulation by Cancer Amplicon Genes
Amplification of a ~2.5 megabase region on chromosome 9p24 is frequent in both primary mediastinal B-cell lymphoma (PMBL) and Hodgkin's lymphoma (HL). To identify the oncogenic genes in this interval, we created a RNA interference library targeting amplicon genes. A genetic screen using this library...
ORGANISM(S): Homo sapiens 
2011-01-04 | E-GEOD-20988 | biostudies-arrayexpress
ProteomicsVincristine resistance reshapes sphingolipid composition and promotes mitochondrial complex I deficiency in acute myelogenous leukemia
Modifications in sphingolipid (SL) metabolism and mitochondrial bioenergetics are key factors implicated in cancer cell response to chemotherapy, including chemotherapy resistance. Vinca alkaloids such as vincristine (VCR), widely used in cancer treatment, are no exception, as their beneficial actio...
ORGANISM(S): Homo Sapiens (human) 
2022-04-21 | PXD025645 | JPOST Repository
TranscriptomicsExpression data from pregnant rat hearts
Hyperhomocysteinemia (HHcy) causes cardiovascular dysfunction and is associated with many complications during pregnancy related to reduced NO bioactivity. The mechanisms of HHcy on the NO-dependent control of myocardial metabolism was compared with L-NAME, which directly inhibits NO bioavailability...
ORGANISM(S): Rattus norvegicus 
2015-06-12 | E-GEOD-30308 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Mycobacterium tuberculosis H37Rv treated with alpibectir or a combination of alpibectir and ethionamide against untreated controls
Alpibectir potentiates the activity of ethionamide and prothionamide, which are second-line antibiotics used for tuberculosis treatment. Both are prodrugs whose antibacterial activity depends on bioactivation by oxidases, including the Baeyer-Villiger monooxygenase MymA. Alpibectir binds the transcr...
ORGANISM(S): Mycobacterium tuberculosis 
2025-12-10 | E-MTAB-16253 | biostudies-arrayexpress
TranscriptomicsGene expression comparison of L. reuteri ATCC PTA 6475 and tetrahydrofolate synthase 2 mutant
Gene expression comparison of L. reuteri ATCC PTA 6475 and tetrahydrofolate synthase 2 mutant in MRS medium in anaerobic conditions at 37C. Includes 3 biological replicates and dye-swaps for ATCC PTA 6475 versus tetrahydrofolate synthase 2 mutant. Reference time point is L. reuteri ATCC PTA 6475.
ORGANISM(S): Lactobacillus reuteri 
2012-06-10 | E-GEOD-32972 | biostudies-arrayexpress
TranscriptomicsGene expression comparison of L. reuteri ATCC PTA 6475 and tetrahydrofolate synthase 1 mutant
Gene expression comparison of L. reuteri ATCC PTA 6475 and tetrahydrofolate synthase 1 in MRS medium in anaerobic conditions at 37C. Includes 3 biological replicates and dye-swaps, with one additional replicate for ATCC PTA 6475 versus tetrahydrofolate synthase 1 mutant. Reference time point is L. ...
ORGANISM(S): Lactobacillus reuteri 
2012-06-10 | E-GEOD-32971 | biostudies-arrayexpress
TranscriptomicsGene expression comparison of L. reuteri ATCC PTA 6475 grown in a glucose-based media and a sucrose-based media
Gene expression comparison of L. reuteri ATCC PTA 6475 grown (stationary phase) in a defined media with either glucose or sucrose as the carbon source, in anaerobic conditions at 37C. Includes 2 biological replicates and dye-swaps for each comparison. Reference time point is is L. reuteri ATCC PTA 6...
ORGANISM(S): Lactobacillus reuteri 
2012-06-11 | E-GEOD-32612 | biostudies-arrayexpress
TranscriptomicsMacrophages recognize the Helicobacter pylori type IV secretion system in the absence of TLR signaling
Helicobacter pylori conquered the world by colonizing the human stomach. There are two major groups of strains, one with and one without a cag pathogenicity island (cagPAI), which result in different clinical outcomes with increased severity in cagPAI+ H. pylori infections such as higher inflammatio...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-56791 | biostudies-arrayexpress
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