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TranscriptomicsTranscription profiling of mice Pax5 targets in B-macrophage bipotential lymphoma cells
B-macrophage bipotential lymphoma cells without Pax5 expression were reconstituted with the Pax5-estrogen receptor fusion protein and changes in transcription profiles in response to 4-hydroxytamoxifen were monitored in vivo
ORGANISM(S): Mus musculus 
2007-09-01 | E-MEXP-1156 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse colon carcinomas over-expressing c-Myc
MycRas vs Ras colon carcinoma. Human adenocarcinomas commonly harbor mutations in the Ki-Ras and c-Myc proto-oncogenes and the trp53 tumor suppressor gene. All three genetic lesions are potentially pro-angiogenic, since they sustain production of the vascular endothelial growth factor (VEGF). Yet m...
ORGANISM(S): Mus musculus 
2006-09-08 | E-MEXP-757 | biostudies-arrayexpress
TranscriptomicsIdentification of Myc-regulated microRNAs in mouse B cell lymphomas
We previously described the use of a spotted oligonucleotide array to identify the mir-17 cluster as a direct transcriptional target of Myc. In order to determine whether Myc regulates additional miRNAs, we produced custom microarrays with an expanded set of probes capable of assaying the expressio...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-9104 | biostudies-arrayexpress
TranscriptomicsIdentification of Myc-regulated microRNAs in human P493 cells
We previously described the use of a spotted oligonucleotide array to identify the mir-17 cluster as a direct transcriptional target of Myc. In order to determine whether Myc regulates additional miRNAs, we produced custom microarrays with an expanded set of probes capable of assaying the expressio...
ORGANISM(S): Homo sapiens 
2007-12-05 | E-GEOD-9070 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human 493-6 cells (human EBV-transformed B lymphocytes) were infected with a retrovirus that produces human Lin-28B or empty virus to identify Myc- and Lin-28B-responsive transcripts
In order to examine the consequences of Myc and Lin-28B induction on the transcriptome, P493-6 cells (human EBV-transformed B lymphocytes) were infected with a retrovirus that produces human Lin-28B or empty virus as a control. Gene expression profiles were then monitored in the high and low Myc sta...
ORGANISM(S): Homo sapiens 
2009-03-14 | E-GEOD-14302 | biostudies-arrayexpress
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