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TranscriptomicsThe role of Ldb1 in hemangioblast development: genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-02-09 | E-GEOD-43044 | biostudies-arrayexpress
TranscriptomicsThymic T-cell progenitor development is supported by membrane bound Kit ligand provided by a combined vascular endothelial and epithelial niche.
Gene expression analysis of purified KitL-tomato+ and KitL-tomato- thymic vascular endothelial cells, cortical and medullary thymic epithelial cells from 5 weeks old male kitL-tomato reporter mice Differentially expressed genes analysis of thymic stromal cells
ORGANISM(S): Mus musculus 
2016-01-18 | E-GEOD-62741 | biostudies-arrayexpress
TranscriptomicsThe role of Ldb1 in hemangioblast development: genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis (sequencing)
The first site exhibiting hematopoietic activity in mammalian development is the yolk sac blood island, which originates from the hemangioblast. Here we performed differentiation assays, as well as genome-wide molecular and functional studies in BL-CFCs to gain insight into the function of the essen...
ORGANISM(S): Mus musculus 
2013-02-09 | E-GEOD-43041 | biostudies-arrayexpress
TranscriptomicsThe role of Ldb1 in hemangioblast development: genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis (Affymetrix)
The first site exhibiting hematopoietic activity in mammalian development is the yolk sac blood island, which originates from the hemangioblast. Here we performed differentiation assays, as well as genome-wide molecular and functional studies in BL-CFCs to gain insight into the function of the essen...
ORGANISM(S): Mus musculus 
2013-02-09 | E-GEOD-43042 | biostudies-arrayexpress
GenomicsIn vivo live imaging of RNA polymerase II transcription factories in primary cells
Transcription steps are marked by different modifications of the C-terminal domain of RNA polymerase II (RNAPII). Phosphorylation of Ser5 and Ser7 by cyclin-dependent kinase 7 (CDK7) as part of TFIIH marks initiation, whereas phosphorylation of Ser2 by CDK9 marks elongation. These processes are thou...
ORGANISM(S): Mus musculus 
2013-05-13 | E-GEOD-46849 | biostudies-arrayexpress
TranscriptomicsSingle cell global gene profiling reveals molecular and functional platelet bias of aged hematopoietic stem cells
Single cell whole transcriptome analysis of young (2-3 months) and old (20-25 months) mouse HSCs, defined as Linâ??Sca-1+c-Kit+150+CD48â?? . Differential gene expression analysis of young and old mouse HSCs (Linâ??Sca-1+c-Kit+150+CD48â?? )
ORGANISM(S): Mus musculus 
2016-03-24 | E-GEOD-70657 | biostudies-arrayexpress
TranscriptomicsLympho-myeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells
An immune-restricted lymphomyeloid-primed progenitor with the capacity to contribute to both myeloid and lymphoid lineages in the developing embryo emerges prior to definitive HSCs. Examination of fetal sorted lymphoid primed progentors and adult progenitors The fastq files are not provided at this...
ORGANISM(S): Mus musculus 
2013-11-26 | E-GEOD-50896 | biostudies-arrayexpress
GenomicsGenome-wide DNA methylation profiles of non-small cell lung carcinomas and control lung tissues
Purpose: Generate genome-wide methylation profiles of non-small cell lung carcinomas (NSCLC) and their matching lung tissues for detection of hypermethylated and hypomethylated regions present in the tumors. Methods: MethylCapture followed by next-generation sequencing (Illumina GAIIx) of 7 nsclc tu...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-41343 | biostudies-arrayexpress
TranscriptomicsGene profiling of platelet-biased long term hematopoietic stem cells
Gene profiling of LSKCD150+CD48-CD34- hemetopoietic stem cells expressing (Vwf+) or not expressing a Vwf-EGFP BAC transgene
ORGANISM(S): Mus musculus 
2013-08-12 | E-MEXP-3935 | biostudies-arrayexpress
TranscriptomicsGene expression in haematopoietic stem and progenitor cells from Gata1-EGFP reporter mouse bone marrow
Haematopoietic stem cells can differentiate into all blood cell types. In this process, cells become progressively restricted to a single cell type. The order in which differentiating cells loose lineage potential, and the prospective isolation of cells with a defined potential remains a long-standi...
ORGANISM(S): Mus musculus 
2016-04-04 | E-GEOD-49241 | biostudies-arrayexpress
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