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TranscriptomicsEffect of rimonabant on gene expression of visceral and subcutaneous adipose tissues: high fat diet
Mice were fed for 6 months with a normal chow (NC) or a high fat diet (HFD). After 6 months of diet, high fat fed mice with Low, Medium and High body weight, but with similar glucose intolerance, were selected. These selected mice as well as NC mice were then treated with Rimonabant or Vehicle for 1...
ORGANISM(S): Mus musculus 
2008-12-14 | E-GEOD-11790 | biostudies-arrayexpress
TranscriptomicsMolecular phenotyping of multiple mouse strains under metabolic challenge uncovers Elovl2 as a novel regulator of glucose-induced insulin secretion
Defective insulin secretion by pancreatic β cells underlies the development of type 2 diabetes (T2D). High fat diet-fed mice are commonly used to study diabetes progression, but studies are usually limited to a single strain, such as C57Bl/6J. Here, we use a systems biology approach to integrate la...
ORGANISM(S): Mus musculus 
2017-04-28 | E-GEOD-78183 | biostudies-arrayexpress
TranscriptomicsEffect of High Fat Diet on gene expression of liver from obesity-prone (C57BL/6J) and obesity-resistant (A/J) mice
Mice were fed for 2, 10 or 30 days with a normal chow (NC) or a high fat diet (HFD). At each time point, mice were sacrificed and liver samples were collected and immediately frozen in liquid nitrogen. Total RNA from each sample was further extracted, purified, quality-controled before and after amp...
ORGANISM(S): Mus musculus 
2009-08-09 | E-GEOD-12409 | biostudies-arrayexpress
UnknownMolecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for <i>Elovl2</i> in glucose-induced insulin secretion.
Not available
S-EPMC5369210 | biostudies-literature
TranscriptomicsHepatic glucose sensing is required to preserve beta-cell glucose competence
We assessed the impact of glucose transporter Glut2 gene inactivation in adult mouse liver (LG2KO mice). This suppressed hepatic glucose uptake but not glucose output. In the fasted state, expression of carbohydrate responsive element-binding protein (ChREBP) and its glycolytic and lipogenic target ...
ORGANISM(S): Mus musculus 
2013-01-18 | E-GEOD-43581 | biostudies-arrayexpress
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