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ProteomicsMicrobiome-derived hydroxyphenyl propanoate promotes antitumour immunity by enhancing Gasdermin D cleavage in tumour-associated myeloid cells
The microbiome has a significant impact on immune health and response to immune-stimulating treatments, including cancer immunotherapy. However, the molecular mechanisms by which commensal microbes influence cancer immunology remain poorly understood. Here, we report on the discovery of a class of m...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045790 | Pride
Tmt Gasdermin d Hydroxuphenyl pyruvate Thermal profiling Thp1-dual cells 
UnknownCheckpoint Kinase 1 (Chk1) inhibition fails to activate the Stimulator of Interferon Genes (STING) innate immune signalling in a human coculture cancer system.
Not available
S-EPMC8607375 | biostudies-literature
GenomicsB11 cells created by replacing the NRAS-G12D mutation in THP1 cells with a dox-inducible NRAS-G12V mutation
B11 cells created by replacing the NRAS-G12D mutation in THP1 cells with a dox-inducible NRAS-G12V mutation
PRJNA476487 | ENA
TranscriptomicsIdentification of cell-intrinsic effects of clonal hematopoiesis in heart failure
Clonal hematopoiesis of indeterminate potential (CHIP) is caused by somatic mutations in hematopoietic stem cells and is associated with worse prognosis in heart failure patients. Patients harboring CHIP mutations show enhanced inflammation. However, whether these signatures are derived from the rel...
ORGANISM(S): Homo sapiens 
2023-06-15 | E-MTAB-13016 | biostudies-arrayexpress
UnknownUp-regulation of miR-663a inhibits the cancer stem cell-like properties of glioma via repressing the KDM2A-mediated TGF-β/SMAD signaling pathway.
Not available
S-EPMC8565824 | biostudies-literature
GenomicsHuman metapneumovirus and mumps virus alter the m6A landscapes in THP-1-derived immature dendritic cells
Human metapneumovirus and mumps virus alter the m6A landscapes in THP-1-derived immature dendritic cells
PRJNA1473181 | ENA
UnknownImmunostimulatory activity of inactivated environmental Bacillus isolates and their endospores.
Not available
S-EPMC12368082 | biostudies-literature
UnknownEcliptasaponin A alleviates inflammation and fibrosis in experimental MASH mice via targeting the NLRP3 inflammasome and YAP signaling pathway.
Not available
S-EPMC12797505 | biostudies-literature
UnknownMelatonin alleviates vascular endothelial cell damage by regulating an autophagy-apoptosis axis in Kawasaki disease.
Not available
S-EPMC9201377 | biostudies-literature
UnknownReplication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity.
Not available
S-EPMC3660094 | biostudies-literature
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