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MetabolomicsDissection of two routes to naïve pluripotency using different kinase inhibitors
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
TranscriptomicsThymidine Kinase and mtDNA Depletion in Human Cardiomyopathy: Epigentic and Translational Evidence for Energy Starvation
A comparison of epigenetic nuclear DNA methylation and gene expression changes between human dialated cardiomypathy left ventricle samples and non-failing cardiac left ventricule samples This study addresses how depletion of huaman cardiac left ventricle mitochondrial DNA and epigentic nuclear DNA m...
ORGANISM(S): Homo sapiens 
2013-06-05 | E-GEOD-43435 | biostudies-arrayexpress
ProteomicsERK- and USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and enzyme activity-independent functions for tumor growth
ERK- and USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and enzyme activity-independent functions for tumor growth
ORGANISM(S): Homo Sapiens 
2024-12-05 | PXD058602 |
UnknownProdrug activation by Cryptosporidium thymidine kinase.
Not available
S-EPMC2871459 | biostudies-literature
UnknownExtending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase.
Not available
S-EPMC2701478 | biostudies-literature
UnknownSequence and evolutionary relationships of African swine fever virus thymidine kinase.
Not available
S-EPMC9534224 | biostudies-literature
UnknownSelective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
Not available
S-EPMC1855528 | biostudies-literature
UnknownThymidine kinase 1 through the ages: a comprehensive review.
Not available
S-EPMC7694900 | biostudies-literature
UnknownStructures of thymidine kinase 1 of human and mycoplasmic origin.
Not available
S-EPMC539776 | biostudies-literature
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