Sort   by:  
 Page size 
ProteomicsDual roles of HSP70 chaperone HSPA1 in quality control of nascent and newly synthesized proteins
Exposure to heat stress triggers a well-defined acute response marked by HSF1-dependent transcriptional upregulation of heat shock proteins. Cells allowed to recover acquire thermotolerance, but this adaptation is poorly understood. By quantitative proteomics, we discovered selective upregulation of...
ORGANISM(S): Homo sapiens (Human) 
2021-05-02 | PXD025123 | Pride
Heat shock protein 70 Esophageal cancer Ubiquitin proteasome system (ups) Stress response 
ProteomicsDiscovery of human breast cancer cell MCF7 heat induced proteins by LC-MS/MS
Co-translational degradation via the ubiquitin-proteasome system mediates quality control of 15 – 25% of nascent proteins, a proportion that is known to increase dramatically under proteotoxic stress conditions. Whereas the ubiquitylation machinery involved has been characterized, mechanisms coordin...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020140 | Pride
Chaperones Heat shock response Proteasome Lc-ms/ms 
Sort   by:  
 Page size