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ProteomicsDIA proteomic of serum samples for the exploration of the pathological mechanism of Obstetric Antiphospholipid syndorme
Obstetric Antiphospholipid syndrome (OAPS) is a multisystem disorder characterized by thrombosis and/or recurrent fetal loss. In this study, we aim to further explore the pathological mechanism of OAPS. Herein, we carried out quantitative proteomic analysis of serum samples from OAPS patients and he...
ORGANISM(S): Homo Sapiens 
PXD045626 |
ProteomicsSNAP47 acetylation-dependent regulatory mechanism governing autophagosome-lysosome fusion by modulating the recruitment of HOPS to autophagic vacuoles
Autophagy, a conserved catabolic process implicated in a diverse array of human diseases, requires efficient fusion between autophagosomes and lysosomes to function effectively. Recently, SNAP47 has been identified as a key component of the default SNARE complex mediating autophagosome-lysosome fusi...
ORGANISM(S): Homo Sapiens 
PXD052239 |
ProteomicsSerum Proteomics Identifies Biomarkers for Predicting Non-survivors in Elderly COVID-19 Patients
In December 2022, China ceased the zero-COVID-19 policy, resulting in an increase in hospitalizations and deaths due to COVID-19, particularly among the elderly population. There is a pressing need to understand the disease progress and predict the survival outcomes of elderly patients to reduce the...
ORGANISM(S): Homo Sapiens 
PXD053895 |
ProteomicsRab10-CAV1 mediated intraluminal vesicles transport to migrasomes
Migrasomes, vesicular organelles generated on the retraction fibers of migrating cells, play a crucial role in migracytosis, mediating intercellular communication. The content cargoes determine the functional specificity of migrasomes. Migrasomes harbor numerous intraluminal vesicles, a pivotal comp...
ORGANISM(S): Mus Musculus 
PXD046146 |
ProteomicsA Micro-Quantitative and FFPE-compatible Workflow for Im- 2 munohistochemistry-Guided Spatial Proteomic Analysis of 3 Cellular Subpopulations within the Tumor Microenvironment
Understanding the spatial proteomic landscape of human tumors is essential for dissecting cellular heterogeneity and microenvironmental interactions in cancer biology. Traditional bulk proteomic approaches, however, obscure spatial information and average out signals from distinct cell populations. ...
ORGANISM(S): Homo Sapiens 
PXD078338 |
ProteomicsProteomic analysis of COVID-19 infection at early stage
We collected 14 patients who tested positive for nasopharyngeal swab real-time PCR for COVID-19 infections, in mild to moderate stage, among which are 6 males and 8 females with ages ranging from 30 to 77. The two control groups were 13 non-COVID-19 pneumonia patients and 10 healthy people. Then we ...
ORGANISM(S): Homo Sapiens 
PXD020522 |
ProteomicsDeep proteomic analysis of circulating large/small extracellular vesicle enriched fraction based on data-independent acquisition mass spectrometry
Proteins in the plasma/serum mirror an individual’s physiology. Circulating extracellular vesicle (EVs) proteins constitute a large portion of the plasma/serum proteome. Thus, deep and unbiased proteomic analysis of circulating plasma/serum extracellular vesicles holds promise for discovering diseas...
ORGANISM(S): Homo Sapiens 
PXD043290 |
ProteomicsN- and O-glycosylation patterns of the SARS-CoV-2 spike protein reveal a new “O- follow-N” rule
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19, has caused a worldwide pandemic since its discovery at the end of 2019. The spike (S) protein of SARS-CoV-2 is responsible for the host cell entry and the critical targets of the immune system. Consequentl...
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
2021-03-24 | PXD023346 |
ProteomicsThe BPAN disease protein WDR45 forms condensates with Caprin-1 to regulate stress granule disassembly
Beta-propeller protein-associated neurodegeneration (BPAN) is a rare X-linked neurodegenerative disorder primarily caused by mutations in the WD repeat domain 45 (WDR45) gene. While WDR45 has traditionally been linked to autophagy, our study uncovers a previously unrecognized role for WDR45 as a cri...
ORGANISM(S): Homo Sapiens 
PXD062911 |
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