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UnknownGestational Caloric Restriction Alters Adipose Tissue Methylome and Offspring's Metabolic Profile in a Swine Model.
Limited nutrient supply to the fetus results in physiologic and metabolic adaptations that have unfavorable consequences in the offspring. In a swine animal model, we aimed to study the effects of gestational caloric restriction and early postnatal metformin administration on offspring's adipose tis...
S-EPMC10816194 | biostudies-literature
UnknownSrc, a potential target for overcoming trastuzumab resistance in HER2-positive breast carcinoma.

Background

Src is a non-receptor tyrosine kinase involved in signalling and crosstalk between growth-promoting pathways. We aim to investigate the relationship of active Src in response to trastuzumab of HER2-positive breast carcinomas.

Methods

We selected 278 HER2-positive breast can...
S-EPMC4134494 | biostudies-literature
UnknownTreatment with anticancer drugs for advanced pancreatic cancer: a systematic review.

Background

Patients with advanced pancreatic cancer have a poor prognosis and high burden of cancer-related symptoms. It is necessary to assess the trade-off of clinical benefits and possible harms of treatments with anticancer drugs (TAD). This systematic review aims to compare the effectiv...
S-EPMC10422698 | biostudies-literature
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